DOT1L

Description		DOT1 like histone lysine methyltransferase
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Protein Binding Methyltransferase Activity Transferase Activity Histone H3K79 Methyltransferase Activity Histone Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization Gene Expression Heterochromatin Formation Subtelomeric Heterochromatin Formation Telomere Organization Methylation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Cycle Regulation Of Transcription Regulatory Region DNA Binding
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 23563607 25282103 18391950 28552196) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878 30578418 30487518 29403010 26390057 27618448) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33493351) Systolic blood pressure ( 30487518 27618448) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Novel Interacting Genes		6 novel interacting genes: H3-4 MAPK11 MLLT10 MYCN STAT1 UBE3C
Interacting Genes		6 interacting genes: H3-4 MAPK11 MLLT10 MYCN STAT1 UBE3C
Entrez ID		84444
HPRD ID		10455
Ensembl ID		ENSG00000104885
Uniprot IDs		A0A8I5QL06 Q8TEK3
PDB IDs		1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96 6TE6 6TEL 6TEN 7BWD 7EDP 7S7E 7S7F 7XCR 7XCT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Erythrocyte Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Autosome Genomic Imprinting Regulation Of Cell Development DNA Binding Cell Population Proliferation Regulation Of Epithelial Cell Differentiation Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation NLRP1 Inflammasome Complex Assembly Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Histone Binding Interleukin-7-mediated Signaling Pathway ISGF3 Complex Negative Regulation By Virus Of Viral Protein Levels In Host Cell Interleukin-27-mediated Signaling Pathway Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal Cell Differentiation Involved In Kidney Development Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Negative Regulation Of Developmental Process Nucleoplasm Regulation Of Inner Ear Auditory Receptor Cell Differentiation Cell Proliferation Involved In Kidney Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Nephron Tubule Epithelial Cell Differentiation Protein K29-linked Ubiquitination Regulation Of Developmental Process Negative Regulation Of Astrocyte Differentiation Cellular Response To UV-B Type II Interferon-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity Positive Regulation Of Gene Expression
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