UTF1 and SOX10

Number of citations of the paper that reports this interaction (PubMedID 16582099)
44

Data Source:
HPRD (in vitro, two hybrid)

		UTF1	SOX10
Description		undifferentiated embryonic cell transcription factor 1	SRY-box transcription factor 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Male Gonad Development Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Neuroblast Proliferation Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Cell Differentiation Melanocyte Differentiation Positive Regulation Of Myelination Developmental Process Lacrimal Gland Development Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Stem Cell Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Cellular Response To Xenobiotic Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of CDH19 Expression and Function Regulation of MITF-M-dependent genes involved in pigmentation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases			Waardenburg syndrome (WS) 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS			Mean spheric corpuscular volume ( 32888494)
Interacting Genes		4 interacting genes: ATF2 SOX10 SOX8 TRIP10	44 interacting genes: ALX4 C10orf55 CDK6 CEBPA CRX CTNNB1 DAZAP2 DLX5 EGR2 ERG EXOC5 GSK3B HHEX HIVEP1 HNF1B HOXA3 HOXC4 HSF4 JUN MAGED1 MAPK1 MEOX1 NFIC NFIX NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 POU6F2 PRRX1 PRRX2 RCAN1 RSPH1 SP1 SUMO1 SUMO2 SUMO3 TCF12 TIAM1 UBE2I UTF1
Entrez ID		8433	6663
HPRD ID		11964	03752
Ensembl ID		ENSG00000171794	ENSG00000100146
Uniprot IDs		Q5T230	P56693
PDB IDs
Enriched GO Terms of Interacting Partners?		Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Peripheral Nervous System Development Enteric Nervous System Development Oligodendrocyte Differentiation Adipose Tissue Development Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Gliogenesis Connective Tissue Development Promoter-specific Chromatin Binding Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Abducens Nucleus Development Hypoglossal Nucleus Development DNA-binding Transcription Factor Activity Glial Cell Differentiation Regulation Of Gliogenesis Fat Cell Differentiation Ameboidal-type Cell Migration Negative Regulation Of Developmental Process Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Growth Plate Cartilage Chondrocyte Proliferation Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium DNA-binding Transcription Factor Binding Cell Maturation Renal Vesicle Induction Response To Anisomycin NK T Cell Differentiation Detection Of Cell Density Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Mitochondrial Outer Membrane Developmental Maturation Cellular Response To Progesterone Stimulus Metanephric Nephron Tubule Formation Astrocyte Fate Commitment	HMG Box Domain Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding System Development Negative Regulation Of RNA Metabolic Process Animal Organ Development Developmental Process Animal Organ Morphogenesis Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Embryonic Organ Morphogenesis Nucleoplasm Ubiquitin Protein Ligase Binding Cell Fate Specification Transcription Coregulator Binding Protein Sumoylation
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