ZMYND12 and ARHGAP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZMYND12	ARHGAP8
Description		zinc finger MYND-type containing 12	Rho GTPase activating protein 8
Image			No pdb structure
GO Annotations	Cellular Component	Cilium Motile Cilium Sperm Flagellum Cell Projection	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	GTPase Activator Activity Protein Binding
	Biological Process	Sperm Axoneme Assembly Flagellated Sperm Motility	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endocytic Recycling
Pathways			RHOA GTPase cycle
Drugs
Diseases
GWAS			Binge eating behaviour in bipolar disorder ( 29391396) Body mass index ( 28552196) Electroencephalographic traits in alcoholism ( 22554406) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Weight ( 28552196)
Interacting Genes		81 interacting genes: ABI2 AIRIM ARHGAP8 ARMC8 ATOSB BMAL1 C1orf50 CCDC116 CCDC24 CHCHD2 CWF19L2 DMRT3 EVX2 FAM222B FAM50B FAM90A1 GPKOW GSTZ1 HAPLN2 HDAC4 HOXB5 HOXC9 HR HSF4 ILF2 INCA1 KANK2 LENG1 LMO2 LMO4 MAD2L2 MNS1 MOAP1 MSGN1 MSRB3 NAB2 NUDT22 ONECUT3 PATL1 PICK1 POM121 POU6F2 PPP1R18 PRKAA2 PRR35 PRR5-ARHGAP8 PRR5L PSMB8 QARS1 RIPPLY1 RUSC1 SAMD11 SAXO1 SAXO4 SCNM1 SDCBP SEC14L4 SH2D4A SHC3 SMARCD1 SMG9 SOHLH1 SPG21 STRA8 TEKT4 TEKT5 TEPSIN TFAP2D THOC1 THRSP TLE5 TSEN54 TSSK3 TTC29 TXN2 TYMP UNC5CL VEZF1 VPS37C ZNF148 ZNF414	7 interacting genes: BNIP2 CFTR CTTN CYGB RHOA SH3GL1 ZMYND12
Entrez ID		84217	23779
HPRD ID		15740	06448
Ensembl ID		ENSG00000066185	ENSG00000241484
Uniprot IDs		B4DX70 Q9H0C1	P85298 Q6PJW1
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Protein Binding Sperm Flagellum Axonemal A Tubule Inner Sheath Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Motile Cilium Regulation Of RNA Metabolic Process Nucleus Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Transcription Coregulator Activity	Regulation Of Smooth Muscle Contraction Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Neuron Differentiation Odontogenesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Muscle Contraction Skeletal Muscle Satellite Cell Migration Cell Projection Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Podosome Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Beta Selection Glutamatergic Synapse Positive Regulation Of Monoatomic Anion Transport Catalase Activity Carbon Monoxide Binding Bone Trabecula Morphogenesis Dendritic Spine Positive Regulation Of Enamel Mineralization Superoxide Dismutase Activity Nitrite Reductase Activity Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Endosome Cleavage Furrow Formation Regulation Of Neuron Differentiation Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Regulation Of Systemic Arterial Blood Pressure By Endothelin Cell Junction Regulation Of Muscle Contraction Positive Regulation Of Protein-containing Complex Assembly Roundabout Signaling Pathway Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Early Endosome Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport
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