SPARCL1 and BTG3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SPARCL1	BTG3
Description		SPARC like 1	BTG anti-proliferation factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Glutamatergic Synapse	Nucleus Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding	Protein Binding
	Biological Process	Signal Transduction Regulation Of Synapse Organization Synaptic Membrane Adhesion	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Idiopathic dilated cardiomyopathy ( 29495422) Urate levels ( 31578528)	Corpus callosum central volume ( 31530798) Feeling hurt ( 29500382)
Interacting Genes		12 interacting genes: BTG3 DISC1 DSCR9 EGFR HUNK LCOR MYCBP2 PDGFRL PRNP RCAN1 SKIL TTC3	76 interacting genes: ADNP2 AFF4 AGAP2 AHCYL1 AIP ATXN1 BANP CACNA1A CCDC13 CCT7 CLTC CLU CNOT7 CNOT8 CNTN4 COPS5 CREBZF CRYL1 DCLK2 DDX18 DIS3L DMAP1 DNAJC14 DNAJC7 DYNC1H1 EIF3C EIF3F EPRS1 GLUL HECTD2 HECTD4 HIVEP2 HSP90AA1 HSP90AB1 KCNQ2 KDM3A KIF3A MAPK8IP3 MORF4L1 MRPL38 MTM1 MYCBP2 NISCH NRBP1 OGT OSBPL8 OTOF PAK1 PAX6 PLA2G3 PLEKHB1 PPP2R5E PPP3CA PRKAR1A QARS1 RANBP9 RBL2 RNF10 RSPH1 SEC23IP SETDB1 SMG5 SPARCL1 SRPK2 SYNE1 TAF1 TAF6 TRIM32 TSC2 TSPAN7 USP8 WAPL WDFY3 XPC ZNF532 ZNF592
Entrez ID		8404	10950
HPRD ID		06919	10415
Ensembl ID		ENSG00000152583	ENSG00000154640
Uniprot IDs		B7ZB68 Q14515 Q8N4S1	Q14201 Q6IAU3
PDB IDs		7KBU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Cerebral Cortex Cell Migration Cellular Response To Estradiol Stimulus Telencephalon Cell Migration Forebrain Cell Migration Skeletal Muscle Tissue Development Learning Or Memory Cognition Intracellular Signal Transduction Identical Protein Binding Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Shc-EGFR Complex Response To Growth Factor Multivesicular Body, Internal Vesicle Lumen Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Synapse Organization Regulation Of Cell Projection Organization Positive Regulation Of Axonogenesis Positive Regulation Of Protein Localization To Membrane Protein-containing Complex Binding Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Platelet Activating Factor Receptor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone	Cytosol Cytoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Establishment Of Localization In Cell Regulation Of Macromolecule Biosynthetic Process Eukaryotic Translation Initiation Factor 3 Complex Organelle Organization Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process RNA Binding Cytoskeleton Organization Chaperone-mediated Protein Complex Assembly Protein Localization To Organelle Translation Initiation Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Unfolded Protein Binding Regulation Of Gene Expression Translation Intracellular Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Intracellular Protein Localization Disordered Domain Specific Binding Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Telomerase Holoenzyme Complex Assembly Negative Regulation Of Catabolic Process CCR4-NOT Core Complex Chromatin Organization 3'-5'-RNA Exonuclease Activity Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding ATP-dependent Protein Folding Chaperone
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