HASPIN and AURKB

Number of citations of the paper that reports this interaction (PubMedID 21658950)
33

Data Source:
BioGRID (enzymatic study)

		HASPIN	AURKB
Description		histone H3 associated protein kinase	aurora kinase B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytoskeleton	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone Kinase Activity Histone H3T3 Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Protein Phosphorylation Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Chromosome Organization Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of B Cell Apoptotic Process Spindle Organization Mitotic Spindle Organization Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Telomere Maintenance Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Regulation Of Microtubule-based Process Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Post-translational Protein Modification Cell Cycle G2/M Phase Transition Mitotic Cytokinesis Checkpoint Signaling Negative Regulation Of Innate Immune Response Mitotic Spindle Midzone Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Midbody Abscission Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Repair Of Mitotic Kinetochore Microtubule Attachment Defect CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Sister Chromatid Biorientation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation
Drugs		5-iodotubercidin 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine H-89 (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol	Hesperidin AT9283 Enzastaurin Reversine Fostamatinib TAK-901
Diseases
GWAS		Parkinson's disease ( 34064523)	Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)
Interacting Genes		7 interacting genes: AURKB CDK1 H3C1 HSF2BP MDFI PDS5B ZNF594	57 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CDH1 CENPA CIB1 DCUN1D1 DES EVI5 FBXL2 FLOT1 GANAB GAS2L3 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LIN28B LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SHCBP1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I USP37
Entrez ID		83903	9212
HPRD ID		17083	05397
Ensembl ID		ENSG00000177602	ENSG00000178999
Uniprot IDs		A0PJ70 Q8TF76	Q96GD4
PDB IDs		2VUW 2WB8 3DLZ 3E7V 3F2N 3FMD 3IQ7 4OUC 4QTC 5HTB 5HTC 6G34 6G35 6G36 6G37 6G38 6G39 6G3A 6Z56 6Z57 6Z58 6Z59 6Z5A 6Z5B 6Z5C 6Z5D 6Z5E 7AVQ 7OPS 7SQM 8RDK 9B2S 9B2T 9B2U 9FLB 9FLC 9FLO 9FLQ 9FLR 9FLT	4AF3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Chromosome Segregation Chromosome Protein Localization To Chromosome, Centromeric Region Spindle Microtubule Cell Cycle G2/M Phase Transition Chromosome Organization Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Nucleoplasm Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Positive Regulation Of Chromosome Organization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cell Division Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Cohesin Unloader Activity Regulation Of Cell Cycle G2/M Phase Transition Organelle Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation Cyclin-dependent Protein Kinase Activity Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Mitotic Cytokinesis Checkpoint Signaling Sister Chromatid Biorientation Cell Cycle Phase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Thymidine Biosynthetic Process Positive Regulation Of Microtubule Depolymerization Golgi Disassembly Nuclear DNA Replication Midbody Histone Kinase Activity Chromosome Passenger Complex Thymidine Metabolic Process	Cell Division Spindle Spindle Organization Cytoskeleton Microtubule Cytoskeleton Organization Spindle Assembly Cytoskeleton Organization Regulation Of Chromosome Separation Microtubule-based Process Regulation Of Cell Cycle Midbody Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Microtubule Binding Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Organelle Organization Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Nuclear Chromosome Segregation Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Positive Regulation Of Chromosome Separation Membraneless Organelle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Cellular Component Organization Chromosome, Centromeric Region Regulation Of Organelle Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Process Microtubule Cytoskeleton Regulation Of Protein-containing Complex Assembly Mitotic Spindle Midzone Assembly Regulation Of Cytokinesis Mitotic Cell Cycle Centrosome Cytoskeleton-dependent Cytokinesis Regulation Of Nuclear Division Mitotic Spindle Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Metaphase Chromosome Alignment Spindle Midzone Assembly Spindle Assembly Involved In Female Meiosis Mitotic Cytokinesis
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