HASPIN

Description		histone H3 associated protein kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone Kinase Activity Histone H3T3 Kinase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Protein Phosphorylation Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Chromosome Organization Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Drugs		5-iodotubercidin 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine H-89 (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol
Diseases
GWAS		Parkinson's disease ( 34064523)
Novel Interacting Genes		7 novel interacting genes: AURKB CDK1 H3C1 HSF2BP MDFI PDS5B ZNF594
Interacting Genes		7 interacting genes: AURKB CDK1 H3C1 HSF2BP MDFI PDS5B ZNF594
Entrez ID		83903
HPRD ID		17083
Ensembl ID		ENSG00000177602
Uniprot IDs		A0PJ70 Q8TF76
PDB IDs		2VUW 2WB8 3DLZ 3E7V 3F2N 3FMD 3IQ7 4OUC 4QTC 5HTB 5HTC 6G34 6G35 6G36 6G37 6G38 6G39 6G3A 6Z56 6Z57 6Z58 6Z59 6Z5A 6Z5B 6Z5C 6Z5D 6Z5E 7AVQ 7OPS 7SQM 8RDK 9B2S 9B2T 9B2U 9FLB 9FLC 9FLO 9FLQ 9FLR 9FLT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Chromosome Segregation Chromosome Protein Localization To Chromosome, Centromeric Region Spindle Microtubule Cell Cycle G2/M Phase Transition Chromosome Organization Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Nucleoplasm Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Positive Regulation Of Chromosome Organization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cell Division Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Cohesin Unloader Activity Regulation Of Cell Cycle G2/M Phase Transition Organelle Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation Cyclin-dependent Protein Kinase Activity Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Mitotic Cytokinesis Checkpoint Signaling Sister Chromatid Biorientation Cell Cycle Phase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Thymidine Biosynthetic Process Positive Regulation Of Microtubule Depolymerization Golgi Disassembly Nuclear DNA Replication Midbody Histone Kinase Activity Chromosome Passenger Complex Thymidine Metabolic Process
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