TMEM120A and GPRC5B

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TMEM120A	GPRC5B
Description		transmembrane protein 120A	G protein-coupled receptor class C group 5 member B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Endoplasmic Reticulum Plasma Membrane Membrane	Extracellular Space Nucleoplasm Nucleolus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft Extracellular Exosome
	Molecular Function	Monoatomic Ion Channel Activity Protein Binding Coenzyme A Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Kinase Binding Protein Kinase Activator Activity Protein Tyrosine Kinase Binding
	Biological Process	Immune System Process Monoatomic Ion Transmembrane Transport Innate Immune Response Fat Cell Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Protein Homooligomerization Protein Heterooligomerization Antiviral Innate Immune Response	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Coffee consumption ( 25288136) Coffee consumption (cups per day) ( 25288136) Sarcoidosis ( 32826979)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758) Body mass index ( 20935630 25673413 26961502 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Hip circumference ( 25673412) L-selectin levels ( 25576479) Menarche (age at onset) ( 25231870) Obesity ( 23563607) Obesity-related traits ( 23251661) Waist circumference ( 25673412)
Interacting Genes		24 interacting genes: AQP6 CYBRD1 FAM209A FBXO7 GOT1 GPRC5B HSD17B13 LEPROT LRRC25 ORMDL2 PAXIP1 PPP1CC PTAFR SCN3B STX1A STX2 TMEM14B TMEM35A TMEM86B TMX2 TPRG1 TSPAN18 UBC VKORC1	7 interacting genes: ADRB2 C11orf71 FUCA2 HSP90AB1 HTR2C TMEM120A TSG101
Entrez ID		83862	51704
HPRD ID		15543	16177
Ensembl ID		ENSG00000189077	ENSG00000167191
Uniprot IDs		A0A087X266 Q9BXJ8	B7Z831 Q9NZH0
PDB IDs		7CXR 7F3T 7F3U 7F6V 7N7P
Enriched GO Terms of Interacting Partners?			Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Fat Cell Differentiation Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Nervous System Process Lysosomal Transport Endosome To Lysosome Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Alpha-L-fucosidase Activity HSP90-CDC37 Chaperone Complex Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Response To Psychosocial Stress Norepinephrine Binding Vacuolar Transport Positive Regulation Of Lipophagy Response To Temperature Stimulus AMPA Selective Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Exosomal Secretion Coenzyme A Binding Protein Homodimerization Activity Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Regulation Of Extracellular Exosome Assembly Positive Regulation Of Autophagosome Maturation Heat Generation Regulation Of Entry Of Bacterium Into Host Cell Glycoside Catabolic Process ATP-dependent Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Aryl Hydrocarbon Receptor Complex Phospholipase C-activating Serotonin Receptor Signaling Pathway Adrenergic Receptor Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Diet Induced Thermogenesis Serotonin Binding Serotonin Receptor Signaling Pathway Virion Binding Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Adhesion Of Symbiont To Host Cell
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