GPRC5B and C11orf71

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GPRC5B	C11orf71
Description		G protein-coupled receptor class C group 5 member B	chromosome 11 open reading frame 71
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Kinase Binding Protein Kinase Activator Activity Protein Tyrosine Kinase Binding
	Biological Process	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758) Body mass index ( 20935630 25673413 26961502 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Hip circumference ( 25673412) L-selectin levels ( 25576479) Menarche (age at onset) ( 25231870) Obesity ( 23563607) Obesity-related traits ( 23251661) Waist circumference ( 25673412)	Asthma ( 21804549 29273806)
Interacting Genes		7 interacting genes: ADRB2 C11orf71 FUCA2 HSP90AB1 HTR2C TMEM120A TSG101	3 interacting genes: APP DKKL1 GPRC5B
Entrez ID		51704	54494
HPRD ID		16177	07874
Ensembl ID		ENSG00000167191	ENSG00000180425
Uniprot IDs		B7Z831 Q9NZH0	A0A0A8K8C2 Q6IPW1
PDB IDs
Enriched GO Terms of Interacting Partners?		Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Fat Cell Differentiation Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Nervous System Process Lysosomal Transport Endosome To Lysosome Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Alpha-L-fucosidase Activity HSP90-CDC37 Chaperone Complex Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Response To Psychosocial Stress Norepinephrine Binding Vacuolar Transport Positive Regulation Of Lipophagy Response To Temperature Stimulus AMPA Selective Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Exosomal Secretion Coenzyme A Binding Protein Homodimerization Activity Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Regulation Of Extracellular Exosome Assembly Positive Regulation Of Autophagosome Maturation Heat Generation Regulation Of Entry Of Bacterium Into Host Cell Glycoside Catabolic Process ATP-dependent Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Aryl Hydrocarbon Receptor Complex Phospholipase C-activating Serotonin Receptor Signaling Pathway Adrenergic Receptor Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Diet Induced Thermogenesis Serotonin Binding Serotonin Receptor Signaling Pathway Virion Binding Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Adhesion Of Symbiont To Host Cell	Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation G Protein-coupled Receptor Binding Cytoplasmic Vesicle Positive Regulation Of Cell Differentiation Acetylcholine Receptor Activator Activity Membrane Raft PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Inflammatory Response Regulation Of Neuron Differentiation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Developmental Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Receptor Complex Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Testosterone Biosynthetic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Extracellular Space Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Cell Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Phosphate Metabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Small Molecule Metabolic Process Axon Choice Point Recognition
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