JAM3 and F2RL2

Number of citations of the paper that reports this interaction (PubMedID 17057644)
19

Data Source:
HPRD (in vitro, in vivo)

		JAM3	F2RL2
Description		junctional adhesion molecule 3	coagulation factor II thrombin receptor like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Membrane Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Anchoring Junction Protein Complex Involved In Cell Adhesion	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane Protein-containing Complex
	Molecular Function	Integrin Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity	Proteinase-activated Receptor Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding Thrombin-activated Receptor Activity Receptor Ligand Activity
	Biological Process	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Cell-matrix Adhesion Spermatogenesis Spermatid Development Cell Migration Transmission Of Nerve Impulse Establishment Of Cell Polarity Cell Differentiation Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization System Development Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability Positive Regulation Of Monocyte Extravasation	Signal Transduction G Protein-coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Response To Wounding Platelet Activation Positive Regulation Of Insulin Secretion Regulation Of Biological Quality Thrombin-activated Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions	Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Neutrophil count ( 32888494)	Mean platelet volume ( 28031487) Phenylephrine infusion rate during anesthesia ( 31455332)
Interacting Genes		8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1	9 interacting genes: AMT CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3
Entrez ID		83700	2151
HPRD ID		06042	03561
Ensembl ID		ENSG00000166086	ENSG00000164220
Uniprot IDs		Q9BX67	O00254
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Establishment Of Protein Localization Cell-cell Adhesion Integrin Binding Integrin Complex Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Tight Junction Podosome Regulation Of Myelination Positive Regulation Of Establishment Of Protein Localization Cell Adhesion Tertiary Granule Membrane Regulation Of Protein Localization Cellular Component Maintenance Plasma Membrane Regulation Of Cell Migration Anchoring Junction Proteinase-activated Receptor Activity Integrin AlphaM-beta2 Complex Integrin-mediated Signaling Pathway Regulation Of Cell Motility Integrin AlphaX-beta2 Complex Regulation Of Locomotion Positive Regulation Of Endothelial Tube Morphogenesis Cell-matrix Adhesion Regulation Of Secretion By Cell Thrombin-activated Receptor Activity Regulation Of Secretion Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Neutrophil Degranulation Response To Curcumin Complement-mediated Synapse Pruning Negative Regulation Of Catecholamine Metabolic Process Vertebrate Eye-specific Patterning Cell-substrate Adhesion Ectodermal Cell Differentiation Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Regulation Of Nervous System Process Positive Regulation Of Cell Motility Somite Specification Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Bicellular Tight Junction Membrane Curvature Sensor Activity Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion	Maintenance Of Blood-brain Barrier Bicellular Tight Junction Cell-cell Junction Anchoring Junction Tight Junction Cell-cell Adhesion Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Platelet Activation Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Leukocyte Migration Platelet Activation Hematopoietic Stem Cell Migration Protein Localization To Cell Junction Neutrophil-mediated Killing Of Bacterium Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Platelet Aggregation Cell-cell Junction Assembly Cell Adhesion Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Protein Localization To Cell-cell Junction Cell Migration Positive Regulation Of Homotypic Cell-cell Adhesion Integrin Binding Neutrophil Mediated Immunity Multicellular Organismal-level Homeostasis Cell-cell Contact Zone Cell-cell Junction Organization Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Platelet Aggregation Killing By Host Of Symbiont Cells Cell-cell Adhesion Mediator Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Biological Process Involved In Interaction With Symbiont Regulation Of Endothelial Cell Differentiation Homeostatic Process Bicellular Tight Junction Assembly Cell Junction Assembly Tight Junction Assembly Adherens Junction Organization Tight Junction Organization Leukocyte Cell-cell Adhesion Positive Regulation Of Calcium Ion Transmembrane Transport Biofilm Matrix Disassembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
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