CASP4 and IL37

Number of citations of the paper that reports this interaction (PubMedID 12096920)
0

Data Source:
BioGRID (enzymatic study)

		CASP4	IL37
Description		caspase 4	interleukin 37
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex NLRP1 Inflammasome Complex Non-canonical Inflammasome Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Lipopolysaccharide Binding Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Lipid Binding Hydrolase Activity CARD Domain Binding	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Immune System Process Proteolysis Apoptotic Process Inflammatory Response Protein Secretion Programmed Cell Death Protein Autoprocessing Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Protein Maturation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Pyroptotic Cell Death Non-canonical Inflammasome Complex Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide
Pathways		NOD1/2 Signaling Pathway Pyroptosis CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4-mediated substrate cleavage	Interleukin-37 signaling Interleukin-18 signaling
Drugs		Incadronic acid
Diseases
GWAS		Major depressive disorder ( 29317602)	Alanine aminotransferase levels ( 33547301) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Pulmonary function ( 23932459) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482)
Interacting Genes		17 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 NOMO1 PLA2G4A PSEN1 SERPINB9	8 interacting genes: CASP1 CASP4 IL18BP IL18R1 PRKAB2 SMAD3 TRIM55 TRIM63
Entrez ID		837	27178
HPRD ID		04047	05695
Ensembl ID		ENSG00000196954	ENSG00000125571
Uniprot IDs		P49662	Q9NZH6
PDB IDs		6KMZ 6NRY 7WR0 7WR1 7WR4 7WR5 7WR6 8J6K 8SPB	5HN1 6NCU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Defense Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Cytokine Production Cell Death Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Immune System Process Regulation Of Programmed Cell Death Regulation Of Interleukin-6 Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Immune Response Execution Phase Of Apoptosis Regulation Of Interleukin-1 Beta Production Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Interleukin-1 Production Defense Response To Gram-positive Bacterium Astrocyte Activation Involved In Immune Response Death Effector Domain Binding Regulation Of Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Response To Lipopolysaccharide Inflammatory Response Apoptotic Signaling Pathway Response To Anesthetic Response To Molecule Of Bacterial Origin Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Multicellular Organismal Process Death-inducing Signaling Complex Natural Killer Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Cell Activation Positive Regulation Of Immune System Process	Interleukin-18-mediated Signaling Pathway Interleukin-18 Binding Immune System Process NLRP1 Inflammasome Complex Immune Response Response To External Biotic Stimulus Canonical Inflammasome Complex CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Stress Protein Autoprocessing Response To Other Organism Defense Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Pyroptotic Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Microtubule Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Signaling Cellular Response To Oxygen-containing Compound Cysteine-type Endopeptidase Activity Non-canonical Inflammasome Complex Negative Regulation Of Lung Blood Pressure Regulation Of Cardiac Muscle Hypertrophy Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Inflammatory Response AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Regulation Of Interleukin-1 Beta Production Positive Regulation Of Transforming Growth Factor Beta3 Production Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Localization To Extracellular Region Positive Regulation Of Cytokine Production AIM2 Inflammasome Complex Regulation Of Interleukin-1 Production IPAF Inflammasome Complex
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