IL37

Description		interleukin 37
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide
Pathways		Interleukin-37 signaling Interleukin-18 signaling
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Pulmonary function ( 23932459) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482)
Novel Interacting Genes		8 novel interacting genes: CASP1 CASP4 IL18BP IL18R1 PRKAB2 SMAD3 TRIM55 TRIM63
Interacting Genes		8 interacting genes: CASP1 CASP4 IL18BP IL18R1 PRKAB2 SMAD3 TRIM55 TRIM63
Entrez ID		27178
HPRD ID		05695
Ensembl ID		ENSG00000125571
Uniprot IDs		Q9NZH6
PDB IDs		5HN1 6NCU
Enriched GO Terms of Interacting Partners?		Interleukin-18-mediated Signaling Pathway Interleukin-18 Binding Immune System Process NLRP1 Inflammasome Complex Immune Response Response To External Biotic Stimulus Canonical Inflammasome Complex CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Stress Protein Autoprocessing Response To Other Organism Defense Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Pyroptotic Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Microtubule Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Signaling Cellular Response To Oxygen-containing Compound Cysteine-type Endopeptidase Activity Non-canonical Inflammasome Complex Negative Regulation Of Lung Blood Pressure Regulation Of Cardiac Muscle Hypertrophy Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Inflammatory Response AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Regulation Of Interleukin-1 Beta Production Positive Regulation Of Transforming Growth Factor Beta3 Production Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Localization To Extracellular Region Positive Regulation Of Cytokine Production AIM2 Inflammasome Complex Regulation Of Interleukin-1 Production IPAF Inflammasome Complex
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