TEX101 and KLHL8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TEX101	KLHL8
Description		testis expressed 101	kelch like family member 8
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Acrosomal Membrane Extracellular Region Plasma Membrane Membrane Cytoplasmic Vesicle Plasma Membrane Raft Membrane Raft Side Of Membrane	Nucleoplasm Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Binding Of Sperm To Zona Pellucida Fertilization Flagellated Sperm Motility Regulation Of Flagellated Sperm Motility	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Cotinine glucuronidation ( 25293881)	Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33547301 33339817) Bulimia nervosa ( 23568457) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 28334899) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010 33339817) Triglycerides ( 20686565 25961943 24097068)
Interacting Genes		3 interacting genes: BRCA1 KLHL8 PICK1	13 interacting genes: ARMC9 ATXN1 CA8 COIL MAPK9 PNMT PPM1F RAPSN RLBP1 SULT2B1 TEX101 TP53I13 USP7
Entrez ID		83639	57563
HPRD ID		15490	13928
Ensembl ID		ENSG00000131126	ENSG00000145332
Uniprot IDs		Q9BY14	B3KY78 Q68DU9 Q9P2G9
PDB IDs		7BPR
Enriched GO Terms of Interacting Partners?		Protein Modification Process Negative Regulation Of Centriole Replication BRCA1-A Complex BRCA1-B Complex Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Cytoskeleton Organization Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Histone H2AK129 Ubiquitin Ligase Activity Response To Indole-3-methanol BRCA1-BARD1 Complex Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Membrane Curvature Sensor Activity Negative Regulation Of Actin Nucleation Negative Regulation Of Centrosome Duplication Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome Neuronal Ion Channel Clustering Arp2/3 Complex Binding Dendritic Spine Maintenance XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Cytoskeleton Organization Long-term Synaptic Depression RNA Polymerase Binding Negative Regulation Of Fatty Acid Biosynthetic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Protein Ubiquitination Regulation Of DNA Damage Checkpoint Negative Regulation Of Cellular Component Organization Protein K6-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Centriole Replication Protein Metabolic Process Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Monoamine Transport Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Condensed Chromosome Mitotic G2 DNA Damage Checkpoint Signaling Postreplication Repair Dendritic Spine Organization
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