RASSF5 and RAP2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RASSF5	RAP2B
Description		Ras association domain family member 5	RAP2B, member of RAS oncogene family
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule	Endosome Cytosol Plasma Membrane Bicellular Tight Junction Endomembrane System Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of Protein Ubiquitination Lymphocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Regulation Of Protein Localization To Nucleus	Signal Transduction Platelet Activation Negative Regulation Of Cell Migration Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Late-onset Alzheimer's disease ( 27770636) Neurofibrillary tangles ( 25188341)	Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)
Interacting Genes		30 interacting genes: ADH6 AMOTL2 APPBP2 BTRC HRAS KRAS KRT40 KRTAP4-2 LSM7 MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 UBQLN2 VPS28	11 interacting genes: CAMK2B PDE6D PRKAR2B RAB40B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A
Entrez ID		83593	5912
HPRD ID		06117	01548
Ensembl ID		ENSG00000266094	ENSG00000181467
Uniprot IDs		A8K5F3 Q8WWW0	P61225
PDB IDs		4LGD 4OH8	1N4P 1N4Q 1N4R
Enriched GO Terms of Interacting Partners?		GDP Binding Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Intracellular Signal Transduction G Protein Activity Ras Protein Signal Transduction GTPase Activity GTP Binding Signal Transduction Cytosol Rap Protein Signal Transduction Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Schwann Cell Migration Regulation Of Signal Transduction Regulation Of Protein Modification Process Regulation Of MAPK Cascade Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Branching Morphogenesis Of An Epithelial Tube Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of JNK Cascade Thioesterase Binding Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Vesicle Membrane Morphogenesis Of An Epithelium Hydrolase Activity Macromolecule Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Modification-dependent Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Protein Modification Process Positive Regulation Of ERAD Pathway Positive Regulation Of Protein Catabolic Process Bounding Membrane Of Organelle Regulation Of Protein Phosphorylation Regulation Of Glial Cell Migration Autophagosome Assembly	Guanyl-nucleotide Exchange Factor Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction GTPase Regulator Activity Signal Transduction Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Intracellular Signal Transduction CAMP Binding Positive Regulation Of Neuron Projection Development Intracellular Signaling Cassette Neurotrophin Signaling Pathway Establishment Of Endothelial Barrier Nervous System Development Endothelial Cell Development Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Regulation Of Neuron Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To CAMP Regulation Of Cell Projection Organization CAAX-box Protein Maturation Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Projection Organization Response To CAMP Positive Regulation Of GTPase Activity Response To Antipsychotic Drug Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Dendrite Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Beta-1 Adrenergic Receptor Binding Regulation Of Neuron Projection Development Positive Regulation Of Hydrolase Activity Myosin Filament Assembly Brain-derived Neurotrophic Factor Receptor Signaling Pathway CAMP-mediated Signaling Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Calcium- And Calmodulin-dependent Protein Kinase Complex System Development Modulation Of Chemical Synaptic Transmission Regulation Of GTPase Activity Epithelial Cell Development Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Microvillus Assembly Response To Purine-containing Compound Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Synapse Structural Plasticity CAMP-dependent Protein Kinase Regulator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?