RAP2B and RAP1GDS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAP2B	RAP1GDS1
Description		RAP2B, member of RAS oncogene family	Rap1 GTPase-GDP dissociation stimulator 1
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GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Bicellular Tight Junction Endomembrane System Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle	Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Signal Transduction Platelet Activation Negative Regulation Of Cell Migration Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Cardiac Muscle Hypertrophy Regulation Of Mitochondrion Organization Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein Localization To Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of ERK5 Cascade CAAX-box Protein Maturation Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Matrix Metallopeptidase Secretion
Pathways		Neutrophil degranulation	RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		11 interacting genes: CAMK2B PDE6D PRKAR2B RAB40B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	27 interacting genes: ABCB7 AKT1 ANTXR2 CDC42 DIRAS1 DOC2A EGFR HRAS KIFAP3 KRAS LCOR LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAC1 RAP1A RAP2B RHOA RNF19B RRAS2 UBC ZNF451
Entrez ID		5912	5910
HPRD ID		01548	11763
Ensembl ID		ENSG00000181467	ENSG00000138698
Uniprot IDs		P61225	B3KNU0 P52306 Q6U7G8
PDB IDs		1N4P 1N4Q 1N4R	5XGC 5ZHX
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction GTPase Regulator Activity Signal Transduction Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Intracellular Signal Transduction CAMP Binding Positive Regulation Of Neuron Projection Development Intracellular Signaling Cassette Neurotrophin Signaling Pathway Establishment Of Endothelial Barrier Nervous System Development Endothelial Cell Development Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Regulation Of Neuron Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To CAMP Regulation Of Cell Projection Organization CAAX-box Protein Maturation Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Projection Organization Response To CAMP Positive Regulation Of GTPase Activity Response To Antipsychotic Drug Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Dendrite Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Beta-1 Adrenergic Receptor Binding Regulation Of Neuron Projection Development Positive Regulation Of Hydrolase Activity Myosin Filament Assembly Brain-derived Neurotrophic Factor Receptor Signaling Pathway CAMP-mediated Signaling Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Calcium- And Calmodulin-dependent Protein Kinase Complex System Development Modulation Of Chemical Synaptic Transmission Regulation Of GTPase Activity Epithelial Cell Development Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Microvillus Assembly Response To Purine-containing Compound Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Synapse Structural Plasticity CAMP-dependent Protein Kinase Regulator Activity	G Protein Activity GTPase Activity GDP Binding GTP Binding Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Glutamatergic Synapse Regulation Of Protein Localization To Membrane Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Regulation Of Locomotion Positive Regulation Of Locomotion Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Phosphorylation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ras Protein Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Positive Regulation Of Epithelial Cell Proliferation Cerebral Cortex Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Modification Process Regulation Of Developmental Process Postsynapse Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Forebrain Radial Glial Cell Differentiation Cell Development Telencephalon Cell Migration Focal Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Positive Regulation Of Cell Cycle Process Cell Migration Forebrain Cell Migration
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