THAP2 and VANGL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		THAP2	VANGL1
Description		THAP domain containing 2	VANGL planar cell polarity protein 1
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GO Annotations	Cellular Component	Nucleus Nucleolus	Extracellular Region Plasma Membrane Membrane Lateral Plasma Membrane
	Molecular Function	DNA Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process		Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway Mucociliary Clearance
Pathways			RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases			Spina bifida Caudal regression syndrome and Sirenomelia
GWAS		Economic and political preferences (time) ( 22566634)	Coronary artery disease ( 33020668) Gut microbiota (bacterial taxa) ( 27694959) Iron status biomarkers (ferritin levels) ( 33536631) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Optic disc size ( 31809533)
Interacting Genes		2 interacting genes: PTPN12 VANGL1	13 interacting genes: CD82 DVL1 DVL2 DVL3 FES GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2 UBC
Entrez ID		83591	81839
HPRD ID		10896	18279
Ensembl ID		ENSG00000173451	ENSG00000173218
Uniprot IDs		Q9H0W7	Q8TAA9
PDB IDs		2D8R	8ZXD 9JK6 9JK8 9JK9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Mucociliary Clearance Negative Regulation Of ERBB Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Podosome Response To Epidermal Growth Factor Cellular Response To Epidermal Growth Factor Stimulus Tissue Regeneration Extracellular Transport Epithelial Cilium Movement Involved In Extracellular Fluid Movement Non-canonical Wnt Signaling Pathway Pigmentation Respiratory System Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lateral Plasma Membrane Regulation Of ERBB Signaling Pathway Protein Dephosphorylation Protein Tyrosine Phosphatase Activity SH3 Domain Binding Regeneration Dephosphorylation	Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Convergent Extension Involved In Neural Plate Elongation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Convergent Extension Involved In Organogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Gastrulation Regulation Of Cell Morphogenesis Convergent Extension Canonical Wnt Signaling Pathway Positive Regulation Of Cell Projection Organization Cochlea Morphogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Localization To Presynapse Wnt Signaling Pathway Small GTPase Binding Clathrin-coated Vesicle Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cell Projection Organization Actin Filament Debranching TRNA 2'-phosphotransferase Activity Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Beta-catenin Binding Nuclear Body Regulation Of Actin Filament-based Process Positive Regulation Of JNK Cascade Phosphorylation Epithelial Tube Morphogenesis Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Histone H3K36 Dimethyltransferase Activity
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