H2BC8 and RAD51B

Number of citations of the paper that reports this interaction (PubMedID 14595808)
0

Data Source:
HPRD (in vitro)

		H2BC8	RAD51B
Description		H2B clustered histone 8	RAD51 paralog B
Image
GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome	Nucleus Nucleoplasm Replication Fork Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Identical Protein Binding Protein Heterodimerization Activity	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Blastocyst Growth DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Somite Development
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 Factors involved in megakaryocyte development and platelet production
Drugs		Copper
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Adverse response to drug ( 30420678) Age-related macular degeneration ( 23455636) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Asthma ( 32296059 30929738 31361310 31619474 31959851 34103634 27182965) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Basophil percentage of white cells ( 32888494) Blond vs. brown/black hair color ( 30531825) Brain asymmetrical skew (vertical) ( 33836062) Breast cancer ( 29059683) Breast cancer (male) ( 23001122) Cancer (pleiotropy) ( 27197191) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Granulocyte count ( 27863252) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Nose size ( 27182965) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes ( 34127860) Type 2 diabetes nephropathy ( 30566433) White blood cell count ( 32888494 27863252)
Interacting Genes		7 interacting genes: AP2M1 ESR1 PTMA RAD51B TGM2 UBR2 YWHAQ	12 interacting genes: ABL1 FADS2 FAM9B H1-0 H2BC8 H3C1 H4C14 MEOX2 RAD51C RAD51D RPAIN SWSAP1
Entrez ID		8339	5890
HPRD ID		11897	04255
Ensembl ID		ENSG00000273802	ENSG00000182185
Uniprot IDs		B2R4S9 P62807	C9JYJ0 O15315
PDB IDs		5GT0 5KGF 6ACO 6C0W 6FML 6R0C 6RNY 6SE0 6SE6 6SEE 6SEF 6SEG 6UPK 6UPL 6X59 6X5A 6XJD 7A08 7JO9 7JOA 7PII 7R5R 7TAN 7TRF 7U46 7U47 7U4D 7U50 7U51 7U52 7U53 7UV9 7Y8R 7YWX 7YYH 8ATF 8AV6 8JBX 8OFF 8OO7 8OOA 8OOP 8OOS 8OX0 8OX1 8QZM 8TXV 8TXW 8TXX 8U13 8VWS 8VWT 8VWU 8VWV 8X15 8X19 8X1C 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9EOZ	8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		14-3-3 Protein Binding Reciprocal Meiotic Recombination Homologous Recombination Chromatin Organization Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Histone H2A Ubiquitin Ligase Activity Transmembrane Transporter Binding Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Nuclear Estrogen Receptor Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Morphogenesis Of A Branching Structure TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Morphogenesis Of A Branching Epithelium Positive Regulation Of Nitric-oxide Synthase Activity Chromatin Remodeling Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Rad51B-Rad51C-Rad51D-XRCC2 Complex Protein Deamination Cellular Response To Serotonin Salivary Gland Cavitation Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Blastocyst Growth Dopamine Secretion Cellular Response To Dopamine Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein-glutamine Gamma-glutamyltransferase Activity L-leucine Binding Postsynaptic Neurotransmitter Receptor Internalization Nitric-oxide Synthase Regulator Activity Response To Dopamine Catecholamine Secretion Cellular Response To Oxygen-containing Compound Prostate Gland Growth Vagina Development	Chromosome Organization Four-way Junction DNA Binding Protein-DNA Complex Assembly Structural Constituent Of Chromatin Nucleosome Assembly DNA Binding Nucleosome Nucleosome Organization Telomere Organization Rad51B-Rad51C-Rad51D-XRCC2 Complex Chromosome Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Protein-containing Complex Assembly Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Protein-containing Complex Organization Replication Fork Reciprocal Meiotic Recombination Nucleoplasm DNA Repair Homologous Recombination Double-strand Break Repair DNA Recombination Negative Regulation Of DNA Recombination Regulation Of Cell Migration Involved In Sprouting Angiogenesis Protein Localization To Cytoplasmic Microtubule Plus-end Female Meiosis Sister Chromatid Cohesion Chromatin Remodeling Transitional One Stage B Cell Differentiation DNA Metabolic Process Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Positive Regulation Of Cellular Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Acyl-CoA Desaturase Activity Shu Complex Protein Heterodimerization Activity DNA Damage Response Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Chromatin Organization Positive Regulation Of Response To Oxidative Stress Stearoyl-CoA 9-desaturase Activity Telomere Maintenance
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