RAD51B and H1-0

Number of citations of the paper that reports this interaction (PubMedID 4595808)
0

Data Source:
HPRD (in vitro)

		RAD51B	H1-0
Description		RAD51 paralog B	H1.0 linker histone
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Rad51B-Rad51C-Rad51D-XRCC2 Complex	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcription Repressor Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosome Binding Nucleosomal DNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Blastocyst Growth DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Somite Development	Nucleosome Assembly Chromosome Condensation Heterochromatin Formation Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 Factors involved in megakaryocyte development and platelet production	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Adverse response to drug ( 30420678) Age-related macular degeneration ( 23455636) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Asthma ( 32296059 30929738 31361310 31619474 31959851 34103634 27182965) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Basophil percentage of white cells ( 32888494) Blond vs. brown/black hair color ( 30531825) Brain asymmetrical skew (vertical) ( 33836062) Breast cancer ( 29059683) Breast cancer (male) ( 23001122) Cancer (pleiotropy) ( 27197191) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Granulocyte count ( 27863252) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Nose size ( 27182965) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes ( 34127860) Type 2 diabetes nephropathy ( 30566433) White blood cell count ( 32888494 27863252)
Interacting Genes		12 interacting genes: ABL1 FADS2 FAM9B H1-0 H2BC8 H3C1 H4C14 MEOX2 RAD51C RAD51D RPAIN SWSAP1	20 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP2 PRKCB RAD51B XBP1
Entrez ID		5890	3005
HPRD ID		04255	00819
Ensembl ID		ENSG00000182185	ENSG00000189060
Uniprot IDs		C9JYJ0 O15315	P07305
PDB IDs		8FAZ 8GBJ 8OUY 8OUZ	6HQ1 6LA2 6LA8 6LA9 6LAB 6N88 6N89 7COW 7DBP 7K5X 7XVL 7XX6 8TB9 9IPU
Enriched GO Terms of Interacting Partners?		Chromosome Organization Four-way Junction DNA Binding Protein-DNA Complex Assembly Structural Constituent Of Chromatin Nucleosome Assembly DNA Binding Nucleosome Nucleosome Organization Telomere Organization Rad51B-Rad51C-Rad51D-XRCC2 Complex Chromosome Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Protein-containing Complex Assembly Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Protein-containing Complex Organization Replication Fork Reciprocal Meiotic Recombination Nucleoplasm DNA Repair Homologous Recombination Double-strand Break Repair DNA Recombination Negative Regulation Of DNA Recombination Regulation Of Cell Migration Involved In Sprouting Angiogenesis Protein Localization To Cytoplasmic Microtubule Plus-end Female Meiosis Sister Chromatid Cohesion Chromatin Remodeling Transitional One Stage B Cell Differentiation DNA Metabolic Process Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Positive Regulation Of Cellular Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Acyl-CoA Desaturase Activity Shu Complex Protein Heterodimerization Activity DNA Damage Response Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Chromatin Organization Positive Regulation Of Response To Oxidative Stress Stearoyl-CoA 9-desaturase Activity Telomere Maintenance	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Nucleus Cytosol Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Positive Regulation Of Establishment Of Protein Localization Nucleus Nuclear Import Signal Receptor Activity Regulation Of Mitotic Cell Cycle Phase Transition Nuclear Localization Sequence Binding G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition NLS-bearing Protein Import Into Nucleus Apoptotic Process Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Programmed Cell Death Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Cyclin Binding Ribosomal Protein Import Into Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Regulation Of Nucleocytoplasmic Transport Intracellular Protein Localization Regulation Of Cell Cycle G2/M Phase Transition Protein Import Into Nucleus DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus Import Into Nucleus DNA Damage Response Histone Kinase Activity Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport
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