CDC45 and CAMK1G

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDC45	CAMK1G
Description		cell division cycle 45	calcium/calmodulin dependent protein kinase IG
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body CMG Complex	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Endomembrane System Membrane
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Replication Checkpoint Signaling Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Mitotic DNA Replication Preinitiation Complex Assembly	Signal Transduction
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs			SU-11652 Fostamatinib
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Amyotrophic lateral sclerosis ( 23624525) Obesity (extreme) ( 21935397)
Interacting Genes		23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CLSPN CSK LCK MAPK3 MCM10 MCM3 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	4 interacting genes: CDC45 KRTAP10-1 KRTAP10-8 PJA1
Entrez ID		8318	57172
HPRD ID		09145	10807
Ensembl ID		ENSG00000093009	ENSG00000008118
Uniprot IDs		O75419	Q96NX5
PDB IDs		5DGO 6XTX 6XTY 7PFO 7PLO	2JAM
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Origin Recognition Complex DNA Replication Origin Binding DNA Replication Nuclear Origin Of Replication Recognition Complex DNA Metabolic Process Chromosome, Telomeric Region Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Mitotic DNA Replication Checkpoint Signaling Nucleoplasm Regulation Of DNA Replication Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2/M Transition Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleotide Binding Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Response Macromolecule Metabolic Process Mitotic DNA Replication Initiation Single-stranded DNA Binding Mitotic G2 DNA Damage Checkpoint Signaling Alpha DNA Polymerase:primase Complex Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Oncogene-induced Cell Senescence ATP Binding Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Cell Cycle CMG Complex MCM Complex Mitotic DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Via Break-induced Replication Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleolus Negative Regulation Of Mitotic Cell Cycle Replicative Senescence DNA Binding Regulation Of DNA-templated DNA Replication Initiation	Mitotic DNA Replication Preinitiation Complex Assembly Keratin Filament DNA Replication Preinitiation Complex Intermediate Filament DNA Replication Preinitiation Complex Assembly CMG Complex Double-strand Break Repair Via Break-induced Replication DNA Replication Origin Binding DNA Replication Checkpoint Signaling
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