CDC45 and POLA1

Number of citations of the paper that reports this interaction (PubMedID 10518787)
0

Data Source:
HPRD (in vitro)

		CDC45	POLA1
Description		cell division cycle 45	DNA polymerase alpha 1, catalytic subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body CMG Complex	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Cytosol Nuclear Matrix
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Protein Kinase Binding DNA Polymerase Activity Metal Ion Binding
	Biological Process	DNA Replication Checkpoint Signaling Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Mitotic DNA Replication Preinitiation Complex Assembly	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis
Drugs			Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CLSPN CSK LCK MAPK3 MCM10 MCM3 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	23 interacting genes: CDC45 CDK1 CDK2 CDK2AP1 GINS4 GLRA2 HELB IL1RAPL1 KLHL15 PARP1 POLA2 POLD1 POLE PRIM2 RAD51 RB1 RBMS1 S100G SERPINA3 SMC1A SUMO2 TP53 XRCC5
Entrez ID		8318	5422
HPRD ID		09145	02416
Ensembl ID		ENSG00000093009	ENSG00000101868
Uniprot IDs		O75419	A6NMQ1 P09884
PDB IDs		5DGO 6XTX 6XTY 7PFO 7PLO	1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7 7N2M 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V 9MJ5
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Origin Recognition Complex DNA Replication Origin Binding DNA Replication Nuclear Origin Of Replication Recognition Complex DNA Metabolic Process Chromosome, Telomeric Region Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Mitotic DNA Replication Checkpoint Signaling Nucleoplasm Regulation Of DNA Replication Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2/M Transition Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleotide Binding Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Response Macromolecule Metabolic Process Mitotic DNA Replication Initiation Single-stranded DNA Binding Mitotic G2 DNA Damage Checkpoint Signaling Alpha DNA Polymerase:primase Complex Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Oncogene-induced Cell Senescence ATP Binding Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Cell Cycle CMG Complex MCM Complex Mitotic DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Via Break-induced Replication Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleolus Negative Regulation Of Mitotic Cell Cycle Replicative Senescence DNA Binding Regulation Of DNA-templated DNA Replication Initiation	DNA Metabolic Process DNA Replication DNA Repair Nucleic Acid Metabolic Process DNA-templated DNA Replication DNA Damage Response Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromosome Organization DNA Replication, Synthesis Of Primer Macromolecule Metabolic Process Chromosome, Telomeric Region Chromatin Binding Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleoplasm Double-strand Break Repair Regulation Of Chromosome Organization Response To Gamma Radiation Macromolecule Biosynthetic Process Negative Regulation Of DNA Metabolic Process Recombinational Repair Chromosome Cellular Response To Radiation DNA Binding G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Kinase Activity DNA Replication Proofreading DNA Biosynthetic Process DNA Replication Initiation Cellular Response To Gamma Radiation Site Of Double-strand Break Telomere Maintenance Nucleus Negative Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome PML Body DNA Recombination Alpha DNA Polymerase:primase Complex Glial Cell Apoptotic Process Response To Radiation Regulation Of Cell Cycle Phase Transition Telomere Organization Histone Kinase Activity Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Cell Cycle Process 4 Iron, 4 Sulfur Cluster Binding Double-strand Break Repair Via Homologous Recombination
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