PICALM and CLTCL1

Number of citations of the paper that reports this interaction (PubMedID 10436022)
36

Data Source:
HPRD (in vivo, in vitro)

		PICALM	CLTCL1
Description		phosphatidylinositol binding clathrin assembly protein	clathrin heavy chain like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cell Surface Endomembrane System Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Endosome To Plasma Membrane Transport Vesicle Neurofibrillary Tangle Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Early Endosome Late Endosome Trans-Golgi Network Spindle Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Of Trans-Golgi Network Vesicle Coated Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Recycling Endosome Extracellular Exosome Clathrin Complex Sorting Endosome
	Molecular Function	SNARE Binding Amyloid-beta Binding Protein Binding Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Small GTPase Binding Clathrin Heavy Chain Binding Cadherin Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding	Structural Molecule Activity Protein Binding Clathrin Light Chain Binding
	Biological Process	Intracellular Iron Ion Homeostasis Endocytosis Receptor-mediated Endocytosis Vesicle Budding From Membrane Axonogenesis Learning Or Memory Negative Regulation Of Gene Expression Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Vesicle Cargo Loading Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Multicellular Organismal-level Iron Ion Homeostasis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Membrane Bending Amyloid-beta Clearance By Transcytosis Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Cell Surface	Mitotic Cell Cycle Intracellular Protein Transport Receptor-mediated Endocytosis Anatomical Structure Morphogenesis Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of D-glucose Import
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RND3 GTPase cycle	Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Alzheimer's disease ( 19734902 21627779 22832961 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Chronic obstructive pulmonary disease ( 30804561) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Mean platelet volume ( 32888494) Platelet count ( 27863252 32888494) Refractive error ( 32231278) Tourette syndrome ( 22889924)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Metabolite levels ( 22916037)
Interacting Genes		21 interacting genes: AP2A1 ATXN1 ATXN1L CASP3 CASP8 CDC42 CLTC CLTCL1 CRX DDIT3 EHD2 EPS15 FCHO1 ITSN1 OGT PELI2 PLCG1 RBPMS SMURF1 TENM1 ZC3H10	5 interacting genes: CDC73 EGFR PICALM SNCA SNX5
Entrez ID		8301	8218
HPRD ID		04320	03172
Ensembl ID		ENSG00000073921	ENSG00000070371
Uniprot IDs		Q13492	A0A087WX41 P53675
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Endocytic Zone Clathrin-coated Pit Clathrin-coated Vesicle Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-dependent Endocytosis Receptor-mediated Endocytosis Import Into Cell Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytosol Intracellular Transport Negative Regulation Of Hyaluronan Biosynthetic Process POZ Domain Binding Endosomal Transport Cytosolic Transport Pyroptotic Inflammatory Response Response To Anesthetic Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Transport Cellular Localization Vesicle-mediated Transport Postsynaptic Neurotransmitter Receptor Internalization Establishment Of Localization In Cell Death-inducing Signaling Complex Clathrin Complex Clathrin Coat Of Coated Pit Clathrin Light Chain Binding Glutamatergic Synapse Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion AP-2 Adaptor Complex Positive Regulation Of Macromolecule Metabolic Process Leucine Zipper Domain Binding Positive Regulation Of Neuron Apoptotic Process Receptor Internalization Intracellular Protein Localization Golgi To Endosome Transport Vesicle-mediated Transport In Synapse Death Receptor Binding Positive Regulation Of Metabolic Process Protein-containing Complex Regulation Of Macromolecule Metabolic Process Endolysosome Membrane Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Transport Execution Phase Of Apoptosis Regulation Of Vesicle-mediated Transport Low-density Lipoprotein Particle Receptor Binding	Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Perinuclear Region Of Cytoplasm Positive Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cadherin Binding Tau Protein Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Fibroblast Proliferation Regulation Of RNA Biosynthetic Process Regulation Of ERBB Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Response To Desipramine Negative Regulation Of Norepinephrine Uptake Regulation Of Amide Metabolic Process Phospholipase D Inhibitor Activity SNARE Binding Positive Regulation Of SNARE Complex Assembly Receptor Internalization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Endocytosis Protein Destabilization Macropinocytic Cup Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of RNA Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Import Into Cell Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Catabolic Process Phospholipid Binding Shc-EGFR Complex Positive Regulation Of RNA Metabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Epidermal Growth Factor Catabolic Process Synaptic Vesicle
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