ARID1A and SMPDL3B

		ARID1A	SMPDL3B
Description		AT-rich interaction domain 1A	sphingomyelin phosphodiesterase acid like 3B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nucleosome Binding	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Metal Ion Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Immune System Process Lipid Metabolic Process Sphingomyelin Catabolic Process Inflammatory Response Lipid Catabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Membrane Lipid Catabolic Process Negative Regulation Of Inflammatory Response
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Positive Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591 30598549) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver volume ( 34128465) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		26 interacting genes: CDC123 EDEM1 ESR1 EWSR1 EZH2 FUS GATA1 GMEB1 HIC1 ITCH KLF1 MLLT1 NCOA1 NEDD4 PGR RARA RARB RARG SMARCA4 SMPDL3B TAF12 TAF15 THEMIS2 TP53 TTC3 VPS41	2 interacting genes: ARID1A OGT
Entrez ID		8289	27293
HPRD ID		04319	15405
Ensembl ID		ENSG00000117713	ENSG00000130768
Uniprot IDs		O14497	B4DEC6 B4DW34 Q92485
PDB IDs		1RYU 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?		Chromatin Nuclear Receptor-mediated Signaling Pathway Regulation Of DNA-templated Transcription Chromatin Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding Transcription Coactivator Binding Nuclear Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Glandular Epithelial Cell Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Growth Plate Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Progesterone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Biosynthetic Process Metal Ion Binding Transcription Regulator Complex Epithelial Cell Development Columnar/cuboidal Epithelial Cell Development Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA Transcription Nuclear Retinoid X Receptor Binding DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Cartilage Development Involved In Endochondral Bone Morphogenesis Embryonic Organ Development Transcription By RNA Polymerase II	Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Regulation Of Transcription By Glucose BBAF Complex NSL Complex Brahma Complex NpBAF Complex NBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Chromatin Organization Acetylglucosaminyltransferase Activity Sin3-type Complex Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Synapse Regulation Of Nucleotide-excision Repair Regulation Of Receptor Localization To Synapse SWI/SNF Complex Regulation Of Necroptotic Process Nucleosome Binding Regulation Of Rac Protein Signal Transduction Regulation Of G0 To G1 Transition Phosphatidylinositol-3,4,5-trisphosphate Binding Cellular Response To Nutrient Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression Transcription Initiation-coupled Chromatin Remodeling Nuclear Receptor Binding Positive Regulation Of Developmental Process Positive Regulation Of Myoblast Differentiation Regulation Of Gluconeogenesis Regulation Of Glycolytic Process Negative Regulation Of Translational Initiation Pyroptotic Inflammatory Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translational Initiation Protein-containing Complex Organization Mitophagy Protein Localization To Lysosome
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