CAPN1 and CTSC

Number of citations of the paper that reports this interaction (PubMedID 12358155)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CAPN1	CTSC
Description		calpain 1	cathepsin C
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Lysosome Endoplasmic Reticulum Lumen Centrosome Membrane COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Dipeptidyl-peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein-folding Chaperone Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway	T Cell Mediated Cytotoxicity Proteolysis Apoptotic Process Immune Response Negative Regulation Of Myelination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Microglial Cell Activation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation
Drugs		4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases			Papillon-Lefevre syndrome Haim-Munk syndrome
GWAS		Urate levels ( 31578528)	Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		59 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BBS9 BCL2L1 BID CAPNS1 CASP14 CAST CBL CD5 CDK4 CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 ELOB F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	5 interacting genes: CAPN1 CTSL PPDPF USP2-AS1 XRN2
Entrez ID		823	1075
HPRD ID		00253	03841
Ensembl ID		ENSG00000014216	ENSG00000109861
Uniprot IDs		B2RDI5 B4DWH5 P07384	P53634
PDB IDs		1ZCM 2ARY 7W7O 7X79 8GX3	1K3B 2DJF 2DJG 3PDF 4CDC 4CDD 4CDE 4CDF 4OEL 4OEM
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization	Calpain Complex Mammary Gland Involution Cysteine-type Peptidase Activity Elastin Metabolic Process Endolysosome Lumen Macrophage Apoptotic Process Elastin Catabolic Process Serpin Family Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Chromaffin Granule Fusion Of Virus Membrane With Host Endosome Membrane Enkephalin Processing Transcription Termination Site Sequence-specific DNA Binding 5'-3' RNA Exonuclease Activity NMDA Selective Glutamate Receptor Signaling Pathway Inflammatory Cell Apoptotic Process Macromolecule Catabolic Process Termination Of RNA Polymerase II Transcription Self Proteolysis 5'-3' Exonuclease Activity Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Receptor-mediated Endocytosis Of Virus By Host Cell Proteoglycan Binding Endocytosis Involved In Viral Entry Into Host Cell Myeloid Cell Apoptotic Process Receptor Catabolic Process Endocytic Vesicle Lumen DNA-templated Transcription Termination Peptidase Activity Response To Thyroid Hormone CD4-positive, Alpha-beta T Cell Lineage Commitment Protein Autoprocessing Alpha-beta T Cell Lineage Commitment Hydrolase Activity Lysosome CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Ionotropic Glutamate Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Fibronectin Binding T Cell Lineage Commitment Glycoprotein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Aggresome 3'-5'-RNA Exonuclease Activity Catabolic Process Ligand-gated Ion Channel Signaling Pathway Collagen Catabolic Process Zymogen Activation
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