CTSC and USP2-AS1

Number of citations of the paper that reports this interaction (PubMedID 36359803)
47

Data Source:
BioGRID (unspecified method)

		CTSC	USP2-AS1
Description		cathepsin C	USP2 antisense RNA 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Lysosome Endoplasmic Reticulum Lumen Centrosome Membrane COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Dipeptidyl-peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein-folding Chaperone Binding
	Biological Process	T Cell Mediated Cytotoxicity Proteolysis Apoptotic Process Immune Response Negative Regulation Of Myelination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Microglial Cell Activation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation
Drugs
Diseases		Papillon-Lefevre syndrome Haim-Munk syndrome
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)	Bitter alcoholic beverage consumption ( 31046077) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Parental longevity (both parents in top 10%) ( 29227965)
Interacting Genes		5 interacting genes: CAPN1 CTSL PPDPF USP2-AS1 XRN2	15 interacting genes: ARIH2 ATR COX15 CTSC DCAF13 ENO2 FAAH2 PCBD2 PEX2 PUS1 RPSA SPRR4 STX10 TP53I3 TSC1
Entrez ID		1075	100499227
HPRD ID		03841
Ensembl ID		ENSG00000109861	ENSG00000245248
Uniprot IDs		P53634
PDB IDs		1K3B 2DJF 2DJG 3PDF 4CDC 4CDD 4CDE 4CDF 4OEL 4OEM
Enriched GO Terms of Interacting Partners?		Calpain Complex Mammary Gland Involution Cysteine-type Peptidase Activity Elastin Metabolic Process Endolysosome Lumen Macrophage Apoptotic Process Elastin Catabolic Process Serpin Family Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Chromaffin Granule Fusion Of Virus Membrane With Host Endosome Membrane Enkephalin Processing Transcription Termination Site Sequence-specific DNA Binding 5'-3' RNA Exonuclease Activity NMDA Selective Glutamate Receptor Signaling Pathway Inflammatory Cell Apoptotic Process Macromolecule Catabolic Process Termination Of RNA Polymerase II Transcription Self Proteolysis 5'-3' Exonuclease Activity Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Receptor-mediated Endocytosis Of Virus By Host Cell Proteoglycan Binding Endocytosis Involved In Viral Entry Into Host Cell Myeloid Cell Apoptotic Process Receptor Catabolic Process Endocytic Vesicle Lumen DNA-templated Transcription Termination Peptidase Activity Response To Thyroid Hormone CD4-positive, Alpha-beta T Cell Lineage Commitment Protein Autoprocessing Alpha-beta T Cell Lineage Commitment Hydrolase Activity Lysosome CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Ionotropic Glutamate Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Fibronectin Binding T Cell Lineage Commitment Glycoprotein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Aggresome 3'-5'-RNA Exonuclease Activity Catabolic Process Ligand-gated Ion Channel Signaling Pathway Collagen Catabolic Process Zymogen Activation
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