PGM1 and DYRK3

Number of citations of the paper that reports this interaction (PubMedID 36585413)
42

Data Source:
BioGRID (two hybrid)

		PGM1	DYRK3
Description		phosphoglucomutase 1	dual specificity tyrosine phosphorylation regulated kinase 3
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Stress Granule Nuclear Speck
	Molecular Function	Magnesium Ion Binding Phosphoglucomutase Activity Protein Binding Isomerase Activity Intramolecular Phosphotransferase Activity Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway	Protein Phosphorylation Erythrocyte Differentiation Nuclear Speck Organization Stress Granule Disassembly Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Division Regulation Of Cellular Response To Stress Positive Regulation Of Cell Cycle G2/M Phase Transition Organelle Disassembly Regulation Of TORC1 Signaling
Pathways		Glycogen synthesis Defective PGM1 causes PGM1-CDG Neutrophil degranulation Glycogen breakdown (glycogenolysis) Galactose catabolism
Drugs		Alpha-D-Glucose 1,6-Bisphosphate Alpha-D-Glucose-1-Phosphate-6-Vanadate
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Type 1 diabetes ( 19430480 32005708 33830302 34012112 34127860) Type 2 diabetes ( 32499647)	Mean corpuscular volume ( 32888494)
Interacting Genes		21 interacting genes: APP CHAF1B DNAJB6 DYRK3 ENO3 HSPB2 KIF1B LINC01554 NLRP3 OGT PAXIP1 PEA15 POT1 S100A1 S100B TERF1 TERF2IP TINF2 TMEM132D USP4 XRN2	12 interacting genes: ACAA2 ADAM22 DNAJA2 DNAJB1 FBXO25 GORASP2 MAGI2 NEDD4L PGM1 PRNP SNAPIN ZNF350
Entrez ID		5236	8444
HPRD ID		01389	04607
Ensembl ID		ENSG00000079739	ENSG00000143479
Uniprot IDs		B4DDQ8 B7Z6C2 P36871	O43781
PDB IDs		5EPC 5F9C 5HSH 5JN5 5TR2 5VBI 5VEC 5VG7 5VIN 6SNO 6SNP 6SNQ 6UIQ 6UO6 7S0W 7S77	5Y86
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chorion Development Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Assembly Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Telomeric D-loop Disassembly Chromosome, Telomeric Region Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region RAGE Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process S100 Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Cellular Component Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process DNA Metabolic Process Regulation Of Chromosome Organization Regulation Of TORC1 Signaling Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Unfolded Protein Binding Regulation Of Cellular Response To Stress Identical Protein Binding Chromosome Organization	Protein-folding Chaperone Binding
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