SEH1L and ATP6V0A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SEH1L	ATP6V0A1
Description		SEH1 like nucleoporin	ATPase H+ transporting V0 subunit a1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Chromosome Lysosome Lysosomal Membrane Cytosol Membrane Nuclear Pore Outer Ring Seh1-associated Complex GATOR2 Complex	Vacuolar Proton-transporting V-type ATPase, V0 Domain Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Vacuolar Proton-transporting V-type ATPase Complex Nuclear Speck Clathrin-coated Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Melanosome Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Nucleocytoplasmic Transport Nuclear Pore Organization Chromosome Segregation Mitotic Metaphase Chromosome Alignment Protein Transport Protein-containing Complex Localization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Defense Response To Gram-positive Bacterium MRNA Transport Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		Amino acids regulate mTORC1	ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Lateral ventricle volume ( 31530798) Lead levels in blood ( 25820613) Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) ( 28521775)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: ATP6V0A1 CEBPA CRYAA PPP1CA	8 interacting genes: ABLIM2 CLIC1 CYTH2 HRH1 SEH1L SNX4 TTC3 ZNF267
Entrez ID		81929	535
HPRD ID		15319	01886
Ensembl ID		ENSG00000085415	ENSG00000033627
Uniprot IDs		Q96EE3	A0A994J3Z0 A0A994J3Z4 A0A994J3Z9 B7Z2A9 B7Z641 K7EN36 K7ENA1 K7ERA6 Q53ET5 Q53X12 Q93050
PDB IDs		5A9Q 7PEQ 7R5J 7R5K 7UHY	6WLW 6WM2 6WM3 6WM4 7U4T
Enriched GO Terms of Interacting Partners?		Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase, V0 Domain Lung Development CHOP-C/EBP Complex Response To Phenylpropanoid Generation Of Precursor Metabolites And Energy Mitochondrion Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Metal Ion Animal Organ Development Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation Tubulin Complex Assembly Protein Stabilization Lens Fiber Cell Morphogenesis Response To Light Stimulus RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Vacuolar Proton-transporting V-type ATPase Complex Response To Lithium Ion DNA-templated Transcription Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Protein-containing Complex Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway STAT Family Protein Binding Osteoblast Development Response To UV-A Response To Radiation
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