SEH1L

Description		SEH1 like nucleoporin
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Chromosome Lysosome Lysosomal Membrane Cytosol Membrane Nuclear Pore Outer Ring Seh1-associated Complex GATOR2 Complex
	Molecular Function	Structural Molecule Activity Protein Binding
	Biological Process	Nucleocytoplasmic Transport Nuclear Pore Organization Chromosome Segregation Mitotic Metaphase Chromosome Alignment Protein Transport Protein-containing Complex Localization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Defense Response To Gram-positive Bacterium MRNA Transport Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Lateral ventricle volume ( 31530798) Lead levels in blood ( 25820613) Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) ( 28521775)
Novel Interacting Genes		4 novel interacting genes: ATP6V0A1 CEBPA CRYAA PPP1CA
Interacting Genes		4 interacting genes: ATP6V0A1 CEBPA CRYAA PPP1CA
Entrez ID		81929
HPRD ID		15319
Ensembl ID		ENSG00000085415
Uniprot IDs		Q96EE3
PDB IDs		5A9Q 7PEQ 7R5J 7R5K 7UHY
Enriched GO Terms of Interacting Partners?		Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase, V0 Domain Lung Development CHOP-C/EBP Complex Response To Phenylpropanoid Generation Of Precursor Metabolites And Energy Mitochondrion Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Metal Ion Animal Organ Development Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation Tubulin Complex Assembly Protein Stabilization Lens Fiber Cell Morphogenesis Response To Light Stimulus RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Vacuolar Proton-transporting V-type ATPase Complex Response To Lithium Ion DNA-templated Transcription Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Protein-containing Complex Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway STAT Family Protein Binding Osteoblast Development Response To UV-A Response To Radiation
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