SLIRP and STK40

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLIRP	STK40
Description		SRA stem-loop interacting RNA binding protein	serine/threonine kinase 40
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GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Sperm Flagellum Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Mitochondrial RNA Catabolic Process Mitochondrion Organization Spermatid Development Single Fertilization Flagellated Sperm Motility Mitochondrial MRNA Polyadenylation Negative Regulation Of Mitochondrial MRNA Catabolic Process	Respiratory System Process Glycogen Metabolic Process Regulation Of Gene Expression Lung Development Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways		Mitochondrial RNA degradation Mitochondrial mRNA modification
Drugs
Diseases
GWAS			Neutrophil count ( 32888494)
Interacting Genes		17 interacting genes: AMOT CCDC102B CSNK2A1 DMRTB1 DNAL1 EXOSC8 GOLGA6L9 KRT27 KRT31 KRT40 MTUS2 NDUFAB1 PICK1 PNMA1 RBPMS STK40 WTAP	7 interacting genes: APP COPS6 LRRK2 NEDD4L POLA2 SLIRP SNIP1
Entrez ID		81892	83931
HPRD ID		12639	11359
Ensembl ID		ENSG00000119705	ENSG00000196182
Uniprot IDs		A0A087WUN7 Q9GZT3	Q8N2I9
PDB IDs		8ANY	5L2Q
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Structural Molecule Activity Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Intermediate Filament	Golgi-associated Vesicle Positive Regulation Of Endocytosis Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Positive Regulation Of Protein Catabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Neuromuscular Junction Development Synapse Organization Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Macromolecule Metabolic Process Regulation Of Synapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Depolarization Regulation Of Endocytosis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Acetylcholine Receptor Activator Activity Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Membrane Potential Regulation Of Response To Endoplasmic Reticulum Stress Endocytosis Regulation Of Calcium-mediated Signaling Lipoprotein Particle Cell Junction Organization Positive Regulation Of Protein Import Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
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