SHARPIN and RNF26

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		SHARPIN	RNF26
Description		SHANK associated RH domain interactor	ring finger protein 26
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Synapse LUBAC Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitochondrion Organization Epidermis Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Apoptotic Nuclear Changes Keratinization Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		30 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 PTEN RBCK1 RNF26 RNF31 SHANK1 SHANK2 SHANK3 TIAM1 TNF TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	55 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 VPS11 WRNIP1 YME1L1
Entrez ID		81858	79102
HPRD ID		15463	05842
Ensembl ID		ENSG00000179526	ENSG00000173456
Uniprot IDs		Q6PJD5 Q9H0F6	Q9BY78
PDB IDs		4EMO 5X0W 8K6P
Enriched GO Terms of Interacting Partners?		Integrin Complex Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Synaptic Receptor Adaptor Activity Cellular Extravasation Dendritic Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity Heterotypic Cell-cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Nervous System Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Social Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Signaling Receptor Activity Vocalization Behavior Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Meiotic Chromosome Movement Towards Spindle Pole Cell Adhesion Cell Surface Postsynaptic Specialization Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dopamine Metabolic Process Microglial Cell Activation LUBAC Complex Ionotropic Glutamate Receptor Binding Neuron Projection Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane RNA Strand Annealing Activity Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Positive Regulation Of Dendritic Spine Development Positive Regulation Of DNA-binding Transcription Factor Activity Postsynaptic Membrane Signal Transduction Intracellular Membraneless Organelle Regulation Of Neutrophil Degranulation	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation
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