SPACA1 and EMP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPACA1	EMP3
Description		sperm acrosome associated 1	epithelial membrane protein 3 (MAM blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Inner Acrosomal Membrane Acrosomal Membrane Membrane Cytoplasmic Vesicle	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Acrosome Assembly Spermatogenesis	Apoptotic Process Bleb Assembly
Pathways
Drugs
Diseases
GWAS		Echocardiographic traits ( 17903301) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		25 interacting genes: AGPAT4 ATP6V0B ATP6V0C BNIP3 CACNG7 CD72 CLDN19 CTXN3 EMP1 EMP3 GIMAP5 LSMEM2 NRSN1 NSG1 PLN PMP22 RPRM SERP2 SERTM1 SGCG SMAGP SMIM3 THSD7B TMEM140 TMEM47	43 interacting genes: AQP6 CD79A CLDN2 CLDN7 CREB3L1 CREM EDA ELOVL7 ERGIC3 FAM210B FNDC9 GJA5 GJB1 GPA33 GPR61 IFNGR2 IL3RA KIR3DL3 KLRC1 LDLRAD1 LEUTX LHFPL5 LRRC4C LYVE1 MR1 MS4A3 MUC1 OPRM1 P2RX7 PLEKHB2 RMDN3 SAR1A SECTM1 SIGLECL1 SLAMF8 SLC30A2 SLC35H1 SMIM3 SPACA1 TM4SF18 TMX2 TSPAN12 VSIG1
Entrez ID		81833	2014
HPRD ID		15419	18514
Ensembl ID		ENSG00000118434	ENSG00000142227
Uniprot IDs		Q9HBV2	P54852
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Bleb Assembly Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Endosome Membrane Multivesicular Body Membrane Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Mitochondrion Autophagosome Adaptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle	Membrane Protein Binding Plasma Membrane Gap Junction Assembly Regulation Of T Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Assembly
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