EMP3 and EDA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EMP3	EDA
Description		epithelial membrane protein 3 (MAM blood group)	ectodysplasin A
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Protein Binding	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity
	Biological Process	Apoptotic Process Bleb Assembly	Hair Follicle Development Immune Response Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Skin Development Canonical Wnt Signaling Pathway Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS			Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		43 interacting genes: AQP6 CD79A CLDN2 CLDN7 CREB3L1 CREM EDA ELOVL7 ERGIC3 FAM210B FNDC9 GJA5 GJB1 GPA33 GPR61 IFNGR2 IL3RA KIR3DL3 KLRC1 LDLRAD1 LEUTX LHFPL5 LRRC4C LYVE1 MR1 MS4A3 MUC1 OPRM1 P2RX7 PLEKHB2 RMDN3 SAR1A SECTM1 SIGLECL1 SLAMF8 SLC30A2 SLC35H1 SMIM3 SPACA1 TM4SF18 TMX2 TSPAN12 VSIG1	23 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60
Entrez ID		2014	1896
HPRD ID		18514	02347
Ensembl ID		ENSG00000142227	ENSG00000158813
Uniprot IDs		P54852	A0A0U5J797 Q92838
PDB IDs			1RJ7 1RJ8 7X9G
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Gap Junction Assembly Regulation Of T Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Assembly	Bleb Assembly Membrane Lysosomal Membrane Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Epidermis Development Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Dolichol Kinase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity
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