LMAN2L and TMEM127

		LMAN2L	TMEM127
Description		lectin, mannose binding 2 like	transmembrane protein 127
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle	Cytoplasm Early Endosome Plasma Membrane Membrane
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Metal Ion Binding	Small GTPase Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport	Endosome Organization Negative Regulation Of Cell Population Proliferation Regulation Of TOR Signaling Negative Regulation Of TOR Signaling
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 20351715 21926972 22182935 28072414 31043756 34002096) Blood protein levels ( 30072576)	Type 2 diabetes (adjusted for BMI) ( 30297969)
Interacting Genes		8 interacting genes: AQP2 ATP6V1G3 MAL NEURL3 STARD7 TMEM127 USP39 ZDHHC17	1 interacting genes: LMAN2L
Entrez ID		81562	55654
HPRD ID		17286	07917
Ensembl ID		ENSG00000114988	ENSG00000135956
Uniprot IDs		B4DI83 B4DVH1 B4E308 Q9H0V9	C9J4H2 O75204
PDB IDs
Enriched GO Terms of Interacting Partners?		Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Response To Water Deprivation Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Cellular Response To Water Deprivation Cytoplasmic Vesicle Membrane Protein Localization To Paranode Region Of Axon Membrane Raft Polarization Peptidase Activator Activity Involved In Apoptotic Process Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Ubiquitin-dependent Endocytosis Response To Water Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Metanephric Collecting Duct Development Response To Mercury Ion Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Regulation Of Neurotrophin TRK Receptor Signaling Pathway Mucociliary Clearance Molecular Carrier Activity Type 2 Immune Response Collecting Duct Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Lipid Transfer Activity Vacuolar Proton-transporting V-type ATPase, V1 Domain Water Channel Activity Golgi-associated Vesicle Membrane Vacuolar Proton-transporting V-type ATPase Complex Apical Protein Localization Ubiquinone Biosynthetic Process	D-mannose Binding COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment
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