LMAN2L and USP39

		LMAN2L	USP39
Description		lectin, mannose binding 2 like	ubiquitin specific peptidase 39
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Metal Ion Binding	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein Deubiquitination Cell Division
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 20351715 21926972 22182935 28072414 31043756 34002096) Blood protein levels ( 30072576)	Neurofibrillary tangles ( 31497858)
Interacting Genes		8 interacting genes: AQP2 ATP6V1G3 MAL NEURL3 STARD7 TMEM127 USP39 ZDHHC17	19 interacting genes: ACVR1 APP CCNB1 CEBPA CHEK2 DNAAF5 FXR2 LMAN2L LRRK2 NFKBIA PFKL SAE1 SIRT7 SRPK2 TRAF6 TRIM25 TRIM39 TRIM5 TRIM8
Entrez ID		81562	10713
HPRD ID		17286	07165
Ensembl ID		ENSG00000114988	ENSG00000168883
Uniprot IDs		B4DI83 B4DVH1 B4E308 Q9H0V9	A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9
PDB IDs			3JCR 6AH0 6QW6 6QX9 8H6E 8H6J 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Response To Water Deprivation Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Cellular Response To Water Deprivation Cytoplasmic Vesicle Membrane Protein Localization To Paranode Region Of Axon Membrane Raft Polarization Peptidase Activator Activity Involved In Apoptotic Process Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Ubiquitin-dependent Endocytosis Response To Water Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Metanephric Collecting Duct Development Response To Mercury Ion Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Regulation Of Neurotrophin TRK Receptor Signaling Pathway Mucociliary Clearance Molecular Carrier Activity Type 2 Immune Response Collecting Duct Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Lipid Transfer Activity Vacuolar Proton-transporting V-type ATPase, V1 Domain Water Channel Activity Golgi-associated Vesicle Membrane Vacuolar Proton-transporting V-type ATPase Complex Apical Protein Localization Ubiquinone Biosynthetic Process	Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Transferase Activity Protein Homodimerization Activity Positive Regulation Of Defense Response Defense Response Identical Protein Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Ubiquitination Intracellular Signaling Cassette Host-mediated Suppression Of Symbiont Invasion Protein Modification Process Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization Cellular Response To Stress Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Catabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Metal Ion
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