SLC7A5 and SLC3A2

Number of citations of the paper that reports this interaction (PubMedID 11311135)
18

Data Source:
HPRD (in vitro)

		SLC7A5	SLC3A2
Description		solute carrier family 7 member 5	solute carrier family 3 member 2
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane Extracellular Exosome External Side Of Apical Plasma Membrane Amino Acid Transport Complex	Nucleoplasm Lysosome Lysosomal Membrane Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Melanosome Neuronal Cell Body Apical Pole Of Neuron Synapse Extracellular Exosome Anchoring Junction Amino Acid Transport Complex
	Molecular Function	Protein Binding Amino Acid Transmembrane Transporter Activity Aromatic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity L-tryptophan Transmembrane Transporter Activity Antiporter Activity Thyroid Hormone Transmembrane Transporter Activity Transmembrane Transporter Activity Peptide Antigen Binding	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Protein Binding Aromatic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Exogenous Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Involved In Immune Response Amino Acid Transmembrane Transport Amino Acid Transport Negative Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Neutral Amino Acid Transport L-amino Acid Transport Isoleucine Transport L-leucine Transport Methionine Transport Phenylalanine Transport Proline Transport Tryptophan Transport Tyrosine Transport Valine Transport Alanine Transport Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-4 Production Cellular Response To Glucose Starvation Xenobiotic Transport Transmembrane Transport Response To Hyperoxia Positive Regulation Of Glial Cell Proliferation Thyroid Hormone Transport Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Amino Acid Import Across Plasma Membrane Liver Regeneration Transport Across Blood-brain Barrier L-histidine Transport L-alpha-amino Acid Transmembrane Transport Cellular Response To L-arginine L-leucine Import Across Plasma Membrane L-tryptophan Transmembrane Transport Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of L-leucine Import Across Plasma Membrane	Carbohydrate Metabolic Process Calcium Ion Transport Amino Acid Transport Isoleucine Transport L-leucine Transport Methionine Transport Phenylalanine Transport Proline Transport Tryptophan Transport Tyrosine Transport Valine Transport Response To Exogenous DsRNA Symbiont Entry Into Host Cell Thyroid Hormone Transport L-histidine Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane
Pathways		Basigin interactions Amino acid transport across the plasma membrane Tryptophan catabolism	Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI) Tryptophan catabolism
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum metabolite levels ( 33031748)	Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: SLC3A2 TUBB3	19 interacting genes: CCR4 CEBPA EBP EGFR GPR37 HNRNPD ICAM1 ITGB1 KLHL20 MTNR1B NPSR1 RELA SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 TLCD3A VHL
Entrez ID		8140	6520
HPRD ID		02552	01148
Ensembl ID		ENSG00000103257	ENSG00000168003
Uniprot IDs		Q01650	P08195
PDB IDs		6IRS 6IRT 6JMQ 7DSK 7DSL 7DSN 7DSQ 8IDA 8J8L 8J8M 8KDD 8KDF 8KDG 8KDH 8KDI 8KDJ 8KDN 8KDO 8KDP 8X0W 8XPU	2DH2 2DH3 6IRS 6IRT 6JMQ 6JMR 6S8V 7B00 7CCS 7CMH 7CMI 7DF1 7DSK 7DSL 7DSN 7DSQ 7EPZ 7P9U 7P9V 8A6L 8G0M 8IDA 8J8L 8J8M 8KDD 8KDF 8KDG 8KDH 8KDI 8KDJ 8KDN 8KDO 8KDP 8QEY 8WNS 8WNT 8WNY 8X0W 8XPU 8YLP
Enriched GO Terms of Interacting Partners?		Apical Pole Of Neuron Isoleucine Transport L-histidine Transport Exogenous Protein Binding Methionine Transport L-leucine Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane Phenylalanine Transport Amino Acid Transport Complex L-alanine Transmembrane Transport Neuronal Cell Body Aromatic Amino Acid Transmembrane Transporter Activity Valine Transport Tryptophan Transport L-alanine Import Across Plasma Membrane Tyrosine Transport Netrin Receptor Binding Dorsal Root Ganglion Development L-alanine Transmembrane Transporter Activity L-alanine Transport L-leucine Transport Proline Transport Netrin-activated Signaling Pathway Aromatic Amino Acid Transport Branched-chain Amino Acid Transport Thyroid Hormone Transport Alanine Transport Sulfur Amino Acid Transport Ganglion Development Neutral L-amino Acid Transmembrane Transporter Activity Basic Amino Acid Transport Peptide Binding Amino Acid Import Across Plasma Membrane Response To Exogenous DsRNA Neutral Amino Acid Transport Response To DsRNA L-alpha-amino Acid Transmembrane Transport Basal Plasma Membrane L-amino Acid Transport Double-stranded RNA Binding Organic Cation Transport Amino Acid Transmembrane Transport Virus Receptor Activity Filopodium Intercellular Bridge Cell Periphery Hormone Transport Melanosome Structural Constituent Of Cytoskeleton Amino Acid Transport	L-amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transport L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Amino Acid Transmembrane Transport Negative Regulation Of Programmed Cell Death Amino Acid Transport Branched-chain Amino Acid Transport L-leucine Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Alanine Transport Neutral L-amino Acid Transmembrane Transporter Activity Transmembrane Transporter Activity Negative Regulation Of Apoptotic Process Organic Cation Transport L-leucine Import Across Plasma Membrane Microvillus Membrane Liver Development Response To Amino Acid Regulation Of Apoptotic Process Amino Acid Import Across Plasma Membrane Carboxylic Acid Transport Organic Acid Transport Valine Transport Regulation Of Programmed Cell Death L-leucine Transmembrane Transporter Activity Tryptophan Transport Plasma Membrane Thyroid Hormone Transmembrane Transporter Activity Organic Anion Transport Negative Regulation Of Catabolic Process Basal Plasma Membrane Aromatic Amino Acid Transport Thyroid Hormone Transport Organic Cation Transmembrane Transporter Activity Animal Organ Development Glycine Transport Negative Regulation Of Vasoconstriction Cellular Response To Amino Acid Stimulus Virus Receptor Activity Sulfur Amino Acid Transport Basolateral Plasma Membrane Vascular Process In Circulatory System Neuropeptide Signaling Pathway Learning Or Memory Gland Development Neuropeptide Receptor Activity Basic Amino Acid Transport Response To Cytokine
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