B9D2 and PLEKHG2

		B9D2	PLEKHG2
Description		B9 domain containing 2	pleckstrin homology and RhoGEF domain containing G2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane MKS Complex Ciliary Basal Body Cell Projection	Cytosol
	Molecular Function	Protein Binding Gamma-tubulin Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Cell Projection Organization Cilium Assembly	Regulation Of Actin Filament Polymerization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 32469254) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 27841878)
Interacting Genes		15 interacting genes: ALKBH7 CCDC97 CCNP CEACAM21 CNFN P4HA3 PLEKHA7 PLEKHG2 QARS1 SAXO4 SPAG8 TLX3 VPS25 YIF1B ZNF574	9 interacting genes: ACTN3 APP B9D2 CDC42 GNG2 PIN1 RAC1 RHOA XRN1
Entrez ID		80776	64857
HPRD ID		14613	15148
Ensembl ID		ENSG00000123810	ENSG00000090924
Uniprot IDs		Q9BPU9	E7ESZ3 Q9H7P9
PDB IDs
Enriched GO Terms of Interacting Partners?			Cell Junction Organization Dendrite Positive Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphorus Metabolic Process G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Oxidative Phosphorylation Small GTPase-mediated Signal Transduction Negative Regulation Of Cellular Respiration Cell Projection Regulation Of Synapse Organization Regulation Of Cytokinesis Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Stress Fiber Assembly Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Supramolecular Fiber Organization Actin Filament-based Process Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Signaling Cassette Cellular Response To Catecholamine Stimulus Establishment Of Epithelial Cell Apical/basal Polarity Focal Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Postsynapse Organization Response To Catecholamine Regulation Of Oxidative Phosphorylation Positive Regulation Of Leukocyte Migration GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Motility Regulation Of Cell Division Positive Regulation Of Lamellipodium Assembly Cell-cell Junction Organization Regulation Of Aerobic Respiration Regulation Of Locomotion Positive Regulation Of Cytoskeleton Organization
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