CD276 and BRD8

		CD276	BRD8
Description		CD276 molecule	bromodomain containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane	Nucleosome Swr1 Complex Nucleus Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex
	Molecular Function	Signaling Receptor Binding Protein Binding	Transcription Coactivator Activity Protein Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Type II Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Immune Response T Cell Receptor Signaling Pathway	Chromatin Organization Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways			HATs acetylate histones
Drugs		Omburtamab
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bipolar disorder ( 21738484 31043756) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications ( 28100913) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Tourette syndrome ( 30818990)	Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)
Interacting Genes		5 interacting genes: ACSBG1 ACTL7B BRD8 BRDT VPS26B	15 interacting genes: AGTR1 CD276 EP400 EP400P1 FSD2 IL3 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1
Entrez ID		80381	10902
HPRD ID		05756	04166
Ensembl ID		ENSG00000103855	ENSG00000112983
Uniprot IDs		A0A0C4DGH0 A8K9J6 Q5ZPR3	B4DEG9 B4DMS9 B4DN43 Q9H0E9
PDB IDs
Enriched GO Terms of Interacting Partners?			Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process NuA4 Histone Acetyltransferase Complex DNA Binding Domain Binding Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Receptor Activity Positive Regulation Of Metabolic Process LBD Domain Binding MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Swr1 Complex Regulation Of DNA Repair Positive Regulation Of DNA Recombination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Monocyte Differentiation Nucleosome Regulation Of Cell Cycle RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Regulation Of Lipid Transport Regulation Of DNA Recombination Negative Regulation Of SMAD Protein Signal Transduction Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Double-strand Break Repair Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Chromatin Organization Transcription Coregulator Binding Regulation Of Cholesterol Efflux
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