TARS2 and TNFAIP8L2

		TARS2	TNFAIP8L2
Description		threonyl-tRNA synthetase 2, mitochondrial	TNF alpha induced protein 8 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm Lysosome
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Threonine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Homodimerization Activity	Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Threonyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	Immune System Process T Cell Activation Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Activation
Pathways		Mitochondrial tRNA aminoacylation	PI Metabolism
Drugs		Threonine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Plateletcrit ( 32888494) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body mass index ( 26426971)
Interacting Genes		15 interacting genes: ANP32E ARL6IP1 ASB6 CIART FKBP7 GABPB2 H3C14 HOMEZ PLIN3 SLC17A9 SYPL1 TARS3 TNFAIP8L2 TNFRSF10D ZNF687	4 interacting genes: MAP3K7 OTUD7B SRPK2 TARS2
Entrez ID		80222	79626
HPRD ID		18148	08029
Ensembl ID		ENSG00000143374	ENSG00000163154
Uniprot IDs		Q9BW92 U3KQG0	Q6P589
PDB IDs			3F4M
Enriched GO Terms of Interacting Partners?			Protein Modification Process ATP Binding Phosphorylation Immune Response Protein Serine Kinase Activity Magnesium Ion Binding Protein Phosphorylation Protein Serine/threonine Kinase Activity R-loop Processing Nuclear Speck Organization Positive Regulation Of Cell Cycle Protein Metabolic Process ATAC Complex Positive Regulation Of Cell Size Type II Transforming Growth Factor Beta Receptor Binding Positive Regulation Of JUN Kinase Activity Anoikis Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway I-kappaB Phosphorylation Interleukin-17A-mediated Signaling Pathway Linear Polyubiquitin Binding Interleukin-33-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction MAP Kinase Kinase Kinase Kinase Activity Negative Regulation Of Cytokine Production Toll-like Receptor 3 Signaling Pathway Histone Kinase Activity Regulation Of TORC2 Signaling Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Deubiquitination Positive Regulation Of TORC2 Signaling Mitochondrial Threonyl-tRNA Aminoacylation Threonine-tRNA Ligase Activity Aminoacyl-tRNA Metabolism Involved In Translational Fidelity TRNA Aminoacylation For Mitochondrial Protein Translation Threonyl-tRNA Aminoacylation Aminoacyl-tRNA Deacylase Activity Nucleotide Binding MyD88-dependent Toll-like Receptor Signaling Pathway MAP Kinase Activity Cellular Response To Angiotensin TORC2 Signaling Nuclear Body Organization Intracellular Signal Transduction K48-linked Deubiquitinase Activity Regulation Of Translational Fidelity Protein Kinase Activity
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