TNFAIP8L2 and TARS2

		TNFAIP8L2	TARS2
Description		TNF alpha induced protein 8 like 2	threonyl-tRNA synthetase 2, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Threonine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Homodimerization Activity
	Biological Process	Immune System Process T Cell Activation Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Activation	Translation TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Threonyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways		PI Metabolism	Mitochondrial tRNA aminoacylation
Drugs			Threonine
Diseases
GWAS		Body mass index ( 26426971)	Alanine aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Plateletcrit ( 32888494) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: MAP3K7 OTUD7B SRPK2 TARS2	15 interacting genes: ANP32E ARL6IP1 ASB6 CIART FKBP7 GABPB2 H3C14 HOMEZ PLIN3 SLC17A9 SYPL1 TARS3 TNFAIP8L2 TNFRSF10D ZNF687
Entrez ID		79626	80222
HPRD ID		08029	18148
Ensembl ID		ENSG00000163154	ENSG00000143374
Uniprot IDs		Q6P589	Q9BW92 U3KQG0
PDB IDs		3F4M
Enriched GO Terms of Interacting Partners?		Protein Modification Process ATP Binding Phosphorylation Immune Response Protein Serine Kinase Activity Magnesium Ion Binding Protein Phosphorylation Protein Serine/threonine Kinase Activity R-loop Processing Nuclear Speck Organization Positive Regulation Of Cell Cycle Protein Metabolic Process ATAC Complex Positive Regulation Of Cell Size Type II Transforming Growth Factor Beta Receptor Binding Positive Regulation Of JUN Kinase Activity Anoikis Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway I-kappaB Phosphorylation Interleukin-17A-mediated Signaling Pathway Linear Polyubiquitin Binding Interleukin-33-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction MAP Kinase Kinase Kinase Kinase Activity Negative Regulation Of Cytokine Production Toll-like Receptor 3 Signaling Pathway Histone Kinase Activity Regulation Of TORC2 Signaling Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Deubiquitination Positive Regulation Of TORC2 Signaling Mitochondrial Threonyl-tRNA Aminoacylation Threonine-tRNA Ligase Activity Aminoacyl-tRNA Metabolism Involved In Translational Fidelity TRNA Aminoacylation For Mitochondrial Protein Translation Threonyl-tRNA Aminoacylation Aminoacyl-tRNA Deacylase Activity Nucleotide Binding MyD88-dependent Toll-like Receptor Signaling Pathway MAP Kinase Activity Cellular Response To Angiotensin TORC2 Signaling Nuclear Body Organization Intracellular Signal Transduction K48-linked Deubiquitinase Activity Regulation Of Translational Fidelity Protein Kinase Activity
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