OPA3 and NGLY1

		OPA3	NGLY1
Description		outer mitochondrial membrane lipid metabolism regulator OPA3	N-glycanase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Cytoplasm Cytosol
	Molecular Function		Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Mitochondrion Organization Visual Perception Regulation Of Lipid Metabolic Process Regulation Of Growth Fat Cell Differentiation Neuromuscular Process Bone Development	Protein Folding Glycoprotein Catabolic Process Positive Regulation Of BMP Signaling Pathway
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases		Autosomal dominant optic atrophy (DOA); Kjer's optic neuropathy 3-Methylglutaconic aciduria (MGCA)
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Depression and alcohol dependence ( 22064162)
Interacting Genes		6 interacting genes: APP KDM1A NGLY1 PRMT6 SUV39H1 UBC	26 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBC UBQLN1 UBXN2B VCP VMAC
Entrez ID		80207	55768
HPRD ID		05956	10118
Ensembl ID		ENSG00000125741	ENSG00000151092
Uniprot IDs		B4DK77 Q9H6K4	Q96IV0
PDB IDs			2CCQ 2CM0
Enriched GO Terms of Interacting Partners?		Chromatin Binding Chromatin Remodeling Histone H3 Methyltransferase Activity Neuron Maturation Chromatin Organization Epigenetic Regulation Of Gene Expression Histone Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H2AR3 Methyltransferase Activity Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Purine-containing Compound Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Negative Regulation Of RNA Metabolic Process Growth Cone Filopodium Macromolecule Metabolic Process Lipoprotein Particle Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization ENoSc Complex Telomeric Repeat-containing RNA Binding Regulation Of Signal Transduction By P53 Class Mediator FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Cell Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling	Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Modification-dependent Protein Catabolic Process Proteasome Complex VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Mitotic Spindle Orientation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Microtubule Cytoskeleton Organization Involved In Mitosis Proteolysis Regulation Of Mitotic Centrosome Separation VCP-NPL4-UFD1 AAA ATPase Complex Establishment Of Spindle Localization Spindle Localization Macromolecule Catabolic Process Positive Regulation Of Cell Cycle HMG Box Domain Binding Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Proteasome Binding Ubiquitin-specific Protease Binding ERAD Pathway Autophagosome Assembly Autophagosome Organization Negative Regulation Of Hippo Signaling Nuclear Membrane Reassembly Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Genome Replication Response To Stress Microtubule-based Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Central Nervous System Development Regulation Of Response To Calcium Ion
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