NGLY1 and UBXN2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		NGLY1	UBXN2B
Description		N-glycanase 1	UBX domain protein 2B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Spindle Pole Centrosome
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Ubiquitin Binding
	Biological Process	Protein Folding Glycoprotein Catabolic Process Positive Regulation Of BMP Signaling Pathway	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Membrane Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS			Gallstone disease ( 27094239) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Loneliness ( 27629369) Low density lipoprotein cholesterol levels ( 29403010 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Narcolepsy with cataplexy ( 23496005) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		26 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBC UBQLN1 UBXN2B VCP VMAC	16 interacting genes: CRX INCA1 MEOX1 MEOX2 NGLY1 PAX5 PAX6 PIN1 PPP1R11 PPP1R3A PPP1R7 UBC UBXN6 VAT1L VCP XAF1
Entrez ID		55768	137886
HPRD ID		10118	18973
Ensembl ID		ENSG00000151092	ENSG00000215114
Uniprot IDs		Q96IV0	E5RJ36 Q14CS0
PDB IDs		2CCQ 2CM0	8B5R
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Modification-dependent Protein Catabolic Process Proteasome Complex VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Mitotic Spindle Orientation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Microtubule Cytoskeleton Organization Involved In Mitosis Proteolysis Regulation Of Mitotic Centrosome Separation VCP-NPL4-UFD1 AAA ATPase Complex Establishment Of Spindle Localization Spindle Localization Macromolecule Catabolic Process Positive Regulation Of Cell Cycle HMG Box Domain Binding Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Proteasome Binding Ubiquitin-specific Protease Binding ERAD Pathway Autophagosome Assembly Autophagosome Organization Negative Regulation Of Hippo Signaling Nuclear Membrane Reassembly Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Genome Replication Response To Stress Microtubule-based Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Central Nervous System Development Regulation Of Response To Calcium Ion	Somite Specification Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus HMG Box Domain Binding Segment Specification Somite Development DNA-binding Transcription Factor Activity Protein Phosphatase 1 Binding Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Cis-trans Isomerase Activity Flavin Adenine Dinucleotide Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Retina Development In Camera-type Eye Sclerotome Development Embryonic Pattern Specification Cerebral Cortex Development Habenula Development Pallium Development Ubiquitin Protein Ligase Binding Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Modification-dependent Protein Catabolic Process VCP-NSFL1C Complex Cellular Response To Arsenite Ion Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Endosome To Lysosome Transport Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Proteolysis Cytoplasm Protein Quality Control ERAD Pathway
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