ASRGL1 and MAPK8IP2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ASRGL1	MAPK8IP2
Description		asparaginase and isoaspartyl peptidase 1	mitogen-activated protein kinase 8 interacting protein 2
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Cytoplasm Cytosol	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body
	Molecular Function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Asparaginase Activity Peptidase Activity Beta-aspartyl-peptidase Activity Hydrolase Activity	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding
	Biological Process	Proteolysis L-asparagine Catabolic Process Via L-aspartate	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Phenylalanine metabolism
Drugs		Aspartic acid Asparagine
Diseases
GWAS		Body fat mass ( 28552196) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549) Serum metabolite levels ( 33031748) Trunk fat mass ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)
Interacting Genes		5 interacting genes: ERBB2 GSK3B MAP2K5 MAPK8IP2 TAB1	86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784
Entrez ID		80150	23542
HPRD ID		07006	09674
Ensembl ID		ENSG00000162174	ENSG00000008735
Uniprot IDs		A0A024R573 Q7L266	Q13387
PDB IDs		3TKJ 4ET0 4O0C 4O0D 4O0E 4O0F 4O0G 4O0H 4OSX 4OSY 4PVP 4PVQ 4PVR 4PVS 4ZM9	8RPP
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Growth Regulation Of Apoptotic Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication ERBB3:ERBB2 Complex Regulation Of Growth Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity ERK5 Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Translation RNA Polymerase I Core Binding Positive Regulation Of Cell Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Positive Regulation Of Epithelial Cell Proliferation	MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade
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