MAPK8IP2 and LRP1

Number of citations of the paper that reports this interaction (PubMedID 10827173)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MAPK8IP2	LRP1
Description		mitogen-activated protein kinase 8 interacting protein 2	LDL receptor related protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Nucleus Nucleolus Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Endocytic Vesicle Membrane Receptor Complex Plasma Membrane Protein Complex
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding	Amyloid-beta Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Lipoprotein Particle Receptor Binding
	Biological Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Lipid Transport Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Transport Apoptotic Cell Clearance Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of SMAD Protein Signal Transduction Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Amyloid-beta Clearance Regulation Of Extracellular Matrix Organization Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			Scavenging of heme from plasma Retinoid metabolism and transport
Drugs			Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Von Willebrand factor human Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Abdominal aortic aneurysm ( 22055160 27899403) Adult asthma ( 30787307) Appendicular lean mass ( 33097823) Asthma ( 31959851 31619474 29273806 27182965) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27322543 22683712 21666692 23793025 27182965) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Spontaneous coronary artery dissection ( 32374345 32887874) Triglyceride levels ( 28334899) Triglycerides ( 25961943 24097068 20686565)
Interacting Genes		86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	78 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CLU CSRP2 CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90AA1 HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NAB2 NGF NOS1AP NTF3 NTF4 PDGFB PID1 PIGA PLAT PLAUR PMEL PRKACA PTPN11 RBM11 RIC8B RNF10 SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		23542	4035
HPRD ID		09674	00138
Ensembl ID		ENSG00000008735	ENSG00000123384
Uniprot IDs		Q13387	Q07954 Q59FG2
PDB IDs		8RPP	1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade	Signaling Receptor Binding Extracellular Space Extracellular Region Low-density Lipoprotein Particle Receptor Binding Endoplasmic Reticulum Lumen Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Extracellular Matrix Heparin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Golgi Lumen Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Processing Regulation Of Protein Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Maturation Cell Surface Platelet Alpha Granule Lumen Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Nerve Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Amyloid-beta Binding Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Perinuclear Region Of Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Transport Positive Regulation Of MAPK Cascade
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