SEMA6D and PLXNA1

Number of citations of the paper that reports this interaction (PubMedID 14977921)
38

Data Source:
HPRD (in vivo)

		SEMA6D	PLXNA1
Description		semaphorin 6D	plexin A1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Cell Surface Membrane	Semaphorin Receptor Complex Nucleoplasm Cytosol Plasma Membrane Membrane Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Semaphorin Receptor Binding Chemorepellent Activity Receptor Ligand Activity	Semaphorin Receptor Activity
	Biological Process	Neural Crest Cell Migration T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Nervous System Development Axon Guidance Smooth Muscle Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Migration Ventricular System Development Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Axon Extension Negative Chemotaxis Semaphorin-plexin Signaling Pathway	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Synapse Assembly Regulation Of Smooth Muscle Cell Migration Olfactory Nerve Formation Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Regulation Of Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Neuron Projection Extension
Pathways		Other semaphorin interactions	Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions RHOD GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Antisaccade task score ( 31596458) Attention deficit hyperactivity disorder ( 29325848) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Attention deficit hyperactivity disorder or intracranial volume (pleiotropy) ( 30818988) Attention deficit hyperactivity disorder or putamen volume (pleiotropy) ( 30818988) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Carotid plaque burden (smoking interaction) ( 24954085) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcification ( 23870195) Cuneus cortex volume ( 31530798) Diisocyanate-induced asthma ( 25918132) Eating disorders ( 22911880) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hair greying ( 26926045) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28008999) Lack of perseverance ( 30718321) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung cancer ( 28604730) Lung function (FVC) ( 30061609) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Oily fish consumption ( 32066663) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Pericalcarine cortex volume ( 31530798) Phoneme awareness ( 30741946) Pork consumption ( 32066663) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to radiotherapy in cancer (late toxicity) ( 24785509) Restless legs syndrome ( 29029846) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (current vs never) ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28008999)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Platelet count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 31469255) Weight ( 28552196) Whole-brain volume ( 21116278)
Interacting Genes		5 interacting genes: AFG2B BLOC1S6 COXFA4L3 PLXNA1 SHF	11 interacting genes: AKT1 FES FGFR2 L1CAM NRP1 NRP2 PLXNB1 RAC1 RHOD RND1 SEMA6D
Entrez ID		80031	5361
HPRD ID		10221	11868
Ensembl ID		ENSG00000137872	ENSG00000114554
Uniprot IDs		Q8NFY4	Q9UIW2
PDB IDs			7Y4P 7Y4Q
Enriched GO Terms of Interacting Partners?		Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Hypothalamus Cell Migration T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Olfactory Nerve Formation Bradykinin Biosynthetic Process Positive Regulation Of Developmental Pigmentation Secretion Of Lysosomal Enzymes Adenosine Metabolic Process Intracellular Nitric Oxide Homeostasis Circadian Sleep/wake Cycle Endosome To Melanosome Transport Positive Regulation Of Pigment Cell Differentiation Response To Acetylcholine Microvesicle Contractile Ring Mitotic Spindle Disassembly Preribosome Binding VCP-NPL4-UFD1 AAA ATPase Complex Semaphorin Receptor Complex Semaphorin Receptor Activity Developmental Growth Synaptic Vesicle Docking Anterograde Synaptic Vesicle Transport Regulation Of Developmental Pigmentation Endothelium Development Hypothalamus Development BLOC-1 Complex Retrograde Protein Transport, ER To Cytosol Neuron Projection Development Pigment Granule Localization Establishment Of Melanosome Localization Peptide Biosynthetic Process Circadian Behavior Pigment Cell Differentiation Melanosome Localization Purine Nucleoside Metabolic Process Dentate Gyrus Development Cell-cell Contact Zone Positive Regulation Of Natural Killer Cell Activation Glutamine Metabolic Process Rhythmic Behavior Melanosome Transport Melanocyte Differentiation Pigment Granule Transport Respiratory Chain Complex IV Filamentous Actin Respiratory System Process Glutamate Metabolic Process Protein Exit From Endoplasmic Reticulum	Semaphorin-plexin Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Locomotion Positive Regulation Of Cell Projection Organization Regulation Of Cell Motility Locomotion Chemotaxis Cell Projection Organization Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Regulation Of Cell Development Anatomical Structure Arrangement Regulation Of Anatomical Structure Morphogenesis Cell Migration Regulation Of Cytoskeleton Organization Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Plasma Membrane Positive Regulation Of Cell Migration Regulation Of Cell Migration Motor Neuron Axon Guidance Regulation Of Cell Differentiation Positive Regulation Of Cell Motility Outflow Tract Septum Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Cell Motility Regulation Of Developmental Growth Ameboidal-type Cell Migration Ventral Trunk Neural Crest Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Axonogenesis Regulation Of Organelle Organization Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Positive Regulation Of Developmental Growth Cranial Ganglion Development Trunk Neural Crest Cell Migration Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Nervous System Development
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