PLXNA1 and NRP1

Number of citations of the paper that reports this interaction (PubMedID 36910328)
82

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		PLXNA1	NRP1
Description		plexin A1	neuropilin 1
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Nucleoplasm Cytosol Plasma Membrane Membrane Synapse Extracellular Exosome Glutamatergic Synapse	Semaphorin Receptor Complex Extracellular Region Extracellular Space Cytoplasm Mitochondrion Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Receptor Complex Postsynaptic Membrane Sorting Endosome Glutamatergic Synapse
	Molecular Function	Semaphorin Receptor Activity	Vascular Endothelial Growth Factor Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Protein Kinase Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Synapse Assembly Regulation Of Smooth Muscle Cell Migration Olfactory Nerve Formation Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Regulation Of Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Neuron Projection Extension	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Neural Crest Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Nervous System Development Axon Guidance Axonal Fasciculation Heart Development Motor Neuron Axon Guidance Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Morphogenesis Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Regulation Of Cdc42 Protein Signal Transduction Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Positive Regulation Of Angiogenesis Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development Axon Extension Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Postsynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Protein Localization To Early Endosome Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Otic Placode Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions RHOD GTPase cycle RND1 GTPase cycle	Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions Attachment and Entry
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Platelet count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 31469255) Weight ( 28552196) Whole-brain volume ( 21116278)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Migraine ( 27322543) Reticulocyte count ( 32888494) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 34127860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: AKT1 FES FGFR2 L1CAM NRP1 NRP2 PLXNB1 RAC1 RHOD RND1 SEMA6D	31 interacting genes: CACNB2 FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM MSRB2 NEBL NRP2 PGF PLXNA1 PLXNB1 PTER RPL27 SEMA3A SEMA3B SEMA3C SEMA3F SNCA SNX5 SNX6 TGFBR1 TGFBR2 TGFBR3 USP9X VEGFA VEGFB
Entrez ID		5361	8829
HPRD ID		11868	03642
Ensembl ID		ENSG00000114554	ENSG00000099250
Uniprot IDs		Q9UIW2	A8K9V7 E9PEP6 O14786 Q59F20 Q6X907
PDB IDs		7Y4P 7Y4Q	1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF 6TKK 7JJC 7O1N 7P5U 8C5G 8PFE 9EOU
Enriched GO Terms of Interacting Partners?		Semaphorin-plexin Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Locomotion Positive Regulation Of Cell Projection Organization Regulation Of Cell Motility Locomotion Chemotaxis Cell Projection Organization Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Regulation Of Cell Development Anatomical Structure Arrangement Regulation Of Anatomical Structure Morphogenesis Cell Migration Regulation Of Cytoskeleton Organization Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Plasma Membrane Positive Regulation Of Cell Migration Regulation Of Cell Migration Motor Neuron Axon Guidance Regulation Of Cell Differentiation Positive Regulation Of Cell Motility Outflow Tract Septum Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Cell Motility Regulation Of Developmental Growth Ameboidal-type Cell Migration Ventral Trunk Neural Crest Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Axonogenesis Regulation Of Organelle Organization Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Positive Regulation Of Developmental Growth Cranial Ganglion Development Trunk Neural Crest Cell Migration Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Nervous System Development	Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Semaphorin-plexin Signaling Pathway Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Heparin Binding Chemotaxis Cell Motility Cell Surface Receptor Signaling Pathway Locomotion Vascular Endothelial Growth Factor Signaling Pathway Tissue Morphogenesis Positive Regulation Of Cell Division Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Regulation Of Chemotaxis Neuropilin Binding Angiogenesis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Region Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Semaphorin Receptor Binding Lung Development Anatomical Structure Morphogenesis Regulation Of Cell Division Positive Regulation Of Vasculature Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphate Metabolic Process Chemoattractant Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Developmental Growth Involved In Morphogenesis Neuron Projection Guidance Positive Regulation Of MAPK Cascade Morphogenesis Of An Epithelium Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus
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