WLS and CCR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		WLS	CCR2
Description		Wnt ligand secretion mediator	C-C motif chemokine receptor 2
Image
GO Annotations	Cellular Component	Golgi Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Early Endosome Membrane Extracellular Exosome	Fibrillar Center Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Wnt-protein Binding Identical Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding CCR2 Chemokine Receptor Binding Chemokine (C-C Motif) Ligand 2 Binding Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 7 Binding Identical Protein Binding
	Biological Process	Mesoderm Formation Intracellular Protein Transport Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Midbrain Development Hindbrain Development Exocrine Pancreas Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Wnt Protein Secretion Positive Regulation Of Wnt Protein Secretion Cementum Mineralization Positive Regulation Of Canonical Wnt Signaling Pathway	Blood Vessel Remodeling Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Hemopoiesis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Homeostasis Of Number Of Cells Within A Tissue Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Leukocyte Adhesion To Vascular Endothelial Cell Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Neutrophil Clearance Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Leukocyte Tethering Or Rolling Macrophage Migration Regulation Of Macrophage Migration Regulation Of T Cell Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways		WNT ligand biogenesis and trafficking	Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs			INCB3284 CCX915 Cenicriviroc Plozalizumab
Diseases
GWAS		Bone mineral density (spine) ( 26911590) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femoral neck bone mineral density ( 32239398 29499414) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 22504420 29499414) Perceived intensity of sucrose ( 31005972) Postoperative complication after cardiac surgery ( 30678657) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 23696881) Celiac disease ( 22057235 20190752 24999842 25920553) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494 27863252 29403010) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 28067908 26192919)
Interacting Genes		6 interacting genes: CCR2 DRD2 GPR37 HRH1 OPRM1 SMO	41 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GLA GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM63A TSPAN7 VMA12 WLS
Entrez ID		79971	729230
HPRD ID		10980	19667
Ensembl ID		ENSG00000116729	ENSG00000121807
Uniprot IDs		Q5T9L3	P41597
PDB IDs		7DRT 7KC4 8TZO 8TZP 8TZR 8TZS	2MLO 2MLQ 5T1A 7P8X 7XA3
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Dendrite G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Behavioral Response To Ethanol Response To Histamine Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Negative Regulation Of Cytosolic Calcium Ion Concentration Perikaryon Response To Morphine Negative Regulation Of Secretion Neuropeptide Binding Positive Regulation Of Neurogenesis G-protein Alpha-subunit Binding Dopamine Metabolic Process Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Development Positive Regulation Of Nervous System Development G Protein-coupled Peptide Receptor Activity Homeostasis Of Number Of Cells Within A Tissue Sensory Perception Of Pain Regulation Of Neuroblast Proliferation Catecholamine Metabolic Process Nervous System Process Neuroblast Proliferation Synapse Ciliary Membrane Positive Regulation Of Neural Precursor Cell Proliferation Visual Learning G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Neurogenesis Visual Behavior Regulation Of Multicellular Organism Growth Biogenic Amine Metabolic Process Signal Transduction Negative Regulation Of Protein Secretion Plasma Membrane Positive Regulation Of MAPK Cascade Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Protein Transport Positive Regulation Of Cell Development	Membrane Endoplasmic Reticulum Membrane Regulation Of Protein Transport Positive Regulation Of Protein Localization Plasma Membrane Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization Regulation Of Transport Golgi Membrane Nuclear Envelope Lumen Positive Regulation Of Protein Transport Regulation Of Intracellular Protein Transport
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