CCR2 and DMWD

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR2	DMWD
Description		C-C motif chemokine receptor 2	DM1 locus, WD repeat containing
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Dendrite Cell Projection Perikaryon
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding CCR2 Chemokine Receptor Binding Chemokine (C-C Motif) Ligand 2 Binding Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 7 Binding Identical Protein Binding	Protein Binding Deubiquitinase Activator Activity
	Biological Process	Blood Vessel Remodeling Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Hemopoiesis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Homeostasis Of Number Of Cells Within A Tissue Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Leukocyte Adhesion To Vascular Endothelial Cell Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Neutrophil Clearance Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Leukocyte Tethering Or Rolling Macrophage Migration Regulation Of Macrophage Migration Regulation Of T Cell Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		INCB3284 CCX915 Cenicriviroc Plozalizumab
Diseases
GWAS		Blood protein levels ( 23696881) Celiac disease ( 22057235 20190752 24999842 25920553) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494 27863252 29403010) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 28067908 26192919)	Apolipoprotein B levels ( 32203549) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Hip circumference ( 28552196) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		41 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GLA GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM63A TSPAN7 VMA12 WLS	2 interacting genes: CCR2 PPBP
Entrez ID		729230	1762
HPRD ID		19667	13235
Ensembl ID		ENSG00000121807	ENSG00000185800
Uniprot IDs		P41597	Q09019 Q8WUW6
PDB IDs		2MLO 2MLQ 5T1A 7P8X 7XA3
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Regulation Of Protein Transport Positive Regulation Of Protein Localization Plasma Membrane Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization Regulation Of Transport Golgi Membrane Nuclear Envelope Lumen Positive Regulation Of Protein Transport Regulation Of Intracellular Protein Transport	Leukocyte Chemotaxis Cell Chemotaxis Myeloid Leukocyte Migration Leukocyte Migration Humoral Immune Response Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Chemokine (C-C Motif) Ligand 12 Binding Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 2 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Chemotaxis Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Locomotion CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Neutrophil Clearance Inflammatory Response D-glucose Transmembrane Transporter Activity Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Glial Cell Migration Inflammatory Response To Wounding Regulation Of Glutamate Receptor Signaling Pathway CXCR Chemokine Receptor Binding Positive Regulation Of T Cell Chemotaxis Regulation Of Leukocyte Tethering Or Rolling Regulation Of T Cell Chemotaxis Negative Regulation Of Type 2 Immune Response Positive Regulation Of Cellular Extravasation T Cell Chemotaxis Dendritic Cell Chemotaxis Positive Regulation Of T-helper 1 Type Immune Response Cellular Extravasation Platelet Alpha Granule Cell Migration Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Chemokine Receptor Activity Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Dendritic Cell Migration
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