CEP76 and PKP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP76	PKP1
Description		centrosomal protein 76	plakophilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane Desmosome Perinuclear Region Of Cytoplasm Anchoring Junction Nuclear Stress Granule Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding
	Biological Process	Regulation Of Centriole Replication	Desmosome Assembly Desmosome Maintenance Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Transepithelial Water Transport Ameloblast Differentiation Intermediate Filament Bundle Assembly Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Protein Localization To Membrane
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases			Ectodermal dysplasia/skin fragility syndrome
GWAS			Panic disorder ( 19165232) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		106 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SEC11A SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	18 interacting genes: AP2B1 ARMC8 BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM
Entrez ID		79959	5317
HPRD ID		12694	03579
Ensembl ID		ENSG00000101624	ENSG00000081277
Uniprot IDs		B4DP81 Q8TAP6	Q13835
PDB IDs			1XM9
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Cornified Envelope Desmosome Intermediate Filament Keratin Filament Binding Ficolin-1-rich Granule Membrane Intermediate Filament Organization Scaffold Protein Binding Desmosome Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Cytoskeleton Epidermis Development Anchoring Junction Cell-cell Junction Organization
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