CEP76 and HSF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP76	HSF2
Description		centrosomal protein 76	heat shock transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Centriole Replication	Regulation Of DNA-templated Transcription Spermatogenesis Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Atrial fibrillation ( 30061737 29892015 28416822) Disease progression in age-related macular degeneration ( 29346644) Lymphocyte count ( 32888494 27863252) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 27841878 30224653) Red blood cell count ( 32888494) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Word reading ( 30741946)
Interacting Genes		106 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SEC11A SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85	20 interacting genes: CDC20 CDC27 CEP76 CUL3 DERA HSF1 HSF2BP HSPA4 MECOM MTUS2 NCAPG NUP62 PCGF2 PICK1 PPP2R1A SUMO2 SUMO3 TPM3 TRIM54 UBE2I
Entrez ID		79959	3298
HPRD ID		12694	00779
Ensembl ID		ENSG00000101624	ENSG00000025156
Uniprot IDs		B4DP81 Q8TAP6	Q03933 Q9BS48
PDB IDs			5D8K 5D8L 5HDK 7DCI 7DCU
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Cytoskeleton Regulation Of Cell Cycle Female Meiotic Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Organelle Organization Cytoplasm Centrosome Positive Regulation Of Chromosome Separation PML Body Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Nuclear Division Spindle Pole Positive Regulation Of Cell Cycle Protein Sumoylation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Separation Meiotic Nuclear Division Protein Modification By Small Protein Conjugation Cell Division Protein Tag Activity Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization SUMO Transferase Activity Regulation Of Sister Chromatid Segregation RNA Polymerase II Transcription Initiation Surveillance Post-translational Protein Modification Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Mitotic Nuclear Division Regulation Of Centriole Replication Nucleoplasm Ubiquitin-like Protein Ligase Binding Cytosol Positive Regulation Of Mitotic Cell Cycle Presynaptic Cytosol Postsynaptic Cytosol Mitotic Spindle Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Nuclear RNA Surveillance Cell Cycle Phase Transition Chromosome, Centromeric Region Kinetochore Chromosome RNA Surveillance
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