RPP21 and RPP38

Number of citations of the paper that reports this interaction (PubMedID 11455963)
17

Data Source:
HPRD (two hybrid)

		RPP21	RPP38
Description		ribonuclease P subunit p21	ribonuclease P/MRP subunit p38
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Multimeric Ribonuclease P Complex Endoribonuclease Complex Ribonucleoprotein Complex	Ribonuclease MRP Complex Fibrillar Center Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Multimeric Ribonuclease P Complex
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding Metal Ion Binding	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal RNA Processing TRNA Processing Response To Xenobiotic Stimulus	TRNA 5'-leader Removal RRNA Processing TRNA Processing
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Lung cancer ( 31577861) Moderate to vigorous physical activity levels ( 29899525) Neurociticism ( 29500382) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Type 1 diabetes (age at diagnosis) ( 33179336)	Clozapine-induced agranulocytosis ( 25187353) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		4 interacting genes: RPP30 RPP38 RPP40 TRAF6	9 interacting genes: POP1 POP4 POP7 PTEN RPP14 RPP21 RPP25 RPP30 RPP40
Entrez ID		79897	10557
HPRD ID		15275	09360
Ensembl ID		ENSG00000241370	ENSG00000152464
Uniprot IDs		A0A1U9X8H3 Q9H633	P78345
PDB IDs		6AHR 6AHU	6AHR 6AHU
Enriched GO Terms of Interacting Partners?		Nucleolar Ribonuclease P Complex Ribonuclease MRP Complex Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing TRNA Processing TRNA Metabolic Process RRNA Processing RRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Ribonuclease MRP Activity Nucleobase-containing Compound Metabolic Process RNA Processing Nucleolus Ribonuclease P Complex Interleukin-17A-mediated Signaling Pathway CD40 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Protein Kinase B Binding Interleukin-33-mediated Signaling Pathway T-helper 1 Type Immune Response Interleukin-17-mediated Signaling Pathway RNA Binding Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Positive Regulation Of JUN Kinase Activity Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Bone Remodeling Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Myeloid Dendritic Cell Differentiation Stimulatory C-type Lectin Receptor Signaling Pathway Protein Branched Polyubiquitination Cellular Response To Lectin Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Bone Resorption Positive Regulation Of T Cell Cytokine Production Regulation Of Receptor Localization To Synapse Interleukin-1-mediated Signaling Pathway Positive Regulation Of Osteoclast Differentiation Regulation Of Protein Localization To Synapse Endolysosomal Toll-like Receptor Signaling Pathway	Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Ribonuclease MRP Complex TRNA Processing Nucleolar Ribonuclease P Complex TRNA Metabolic Process RNA Processing Ribonuclease P Complex Nucleolus RNA Metabolic Process RNA Binding RRNA Processing RRNA Metabolic Process Nucleic Acid Metabolic Process Endoribonuclease Complex Nucleoplasm Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Negative Regulation Of Synaptic Vesicle Clustering Ribonuclease MRP Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Presynaptic Membrane Organization Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Postsynaptic Specialization Assembly Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential TRNA Decay Locomotor Rhythm Cellular Response To Electrical Stimulus
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