RPP38 and RPP25

Number of citations of the paper that reports this interaction (PubMedID 15096576)
37

Data Source:
HPRD (in vitro)

		RPP38	RPP25
Description		ribonuclease P/MRP subunit p38	ribonuclease P/MRP subunit p25
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GO Annotations	Cellular Component	Ribonuclease MRP Complex Fibrillar Center Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Multimeric Ribonuclease P Complex	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolus Multimeric Ribonuclease P Complex Centriolar Satellite
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Nucleic Acid Binding RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal RRNA Processing TRNA Processing	TRNA 5'-leader Removal RRNA Processing TRNA Processing
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		9 interacting genes: POP1 POP4 POP7 PTEN RPP14 RPP21 RPP25 RPP30 RPP40	22 interacting genes: ABI2 BACH2 BANP DDI1 HOMEZ KRT15 LDOC1 LRRC73 PDLIM7 PICK1 PNMA1 POP1 POP4 POP5 POP7 RBPMS RPP14 RPP38 SAT1 SF3B4 TERF2IP ZNF438
Entrez ID		10557	54913
HPRD ID		09360	15276
Ensembl ID		ENSG00000152464	ENSG00000178718
Uniprot IDs		P78345	Q9BUL9
PDB IDs		6AHR 6AHU	6AHR 6AHU 6CWX 6LT7
Enriched GO Terms of Interacting Partners?		Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Ribonuclease MRP Complex TRNA Processing Nucleolar Ribonuclease P Complex TRNA Metabolic Process RNA Processing Ribonuclease P Complex Nucleolus RNA Metabolic Process RNA Binding RRNA Processing RRNA Metabolic Process Nucleic Acid Metabolic Process Endoribonuclease Complex Nucleoplasm Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Negative Regulation Of Synaptic Vesicle Clustering Ribonuclease MRP Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Presynaptic Membrane Organization Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Postsynaptic Specialization Assembly Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential TRNA Decay Locomotor Rhythm Cellular Response To Electrical Stimulus	Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Ribonuclease MRP Complex Nucleolar Ribonuclease P Complex Ribonuclease P Complex TRNA Processing TRNA Metabolic Process Nucleolus RNA Processing Nucleoplasm RNA Binding RRNA Processing Nucleus RRNA Metabolic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Spermidine Binding RNA Metabolic Process Primary Adaptive Immune Response Involving T Cells And B Cells Spermidine Acetylation Putrescine Catabolic Process Zonula Adherens Assembly Nucleic Acid Metabolic Process Negative Regulation Of DNA Recombination At Telomere Primary Adaptive Immune Response
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