MCMBP and MCM6

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (affinity chromatography technology, pull down, biochemical)

		MCMBP	MCM6
Description		minichromosome maintenance complex binding protein	minichromosome maintenance complex component 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cell Junction MCM Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytosol MCM Complex CMG Complex
	Molecular Function	Chromatin Binding Protein Binding	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	DNA Replication DNA-templated DNA Replication Sister Chromatid Cohesion Cell Division	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication
Pathways			Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Height ( 28552196)	Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		14 interacting genes: ASL DBF4 DDIT3 FKBP5 KEAP1 MCM3 MCM4 MCM5 MCM6 PRTFDC1 RWDD2A SNW1 USP7 ZNF474	36 interacting genes: ATRIP CATSPERT CCNA1 CDC42 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9
Entrez ID		79892	4175
HPRD ID		07624	03485
Ensembl ID		ENSG00000197771	ENSG00000076003
Uniprot IDs		A0A0S2Z5P5 Q9BTE3	Q14566
PDB IDs		4KG9	2KLQ 2LE8 6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Regulation Of DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Damage Response Regulation Of DNA Metabolic Process Single-stranded DNA Binding Helicase Activity Mitotic DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress Chromosome, Telomeric Region DNA Metabolic Process Double-strand Break Repair DNA Recombination DNA Repair DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Chromosome ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process DNA Helicase Activity Transcription Regulator Inhibitor Activity Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Argininosuccinate Lyase Activity Ammonia Assimilation Cycle Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Nucleoplasm L-arginine Biosynthetic Process Via Ornithine Nitrogen Utilization Negative Regulation Of Determination Of Dorsal Identity Response To Stress Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CHOP-ATF4 Complex CHOP-ATF3 Complex Dbf4-dependent Protein Kinase Complex Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage CHOP-C/EBP Complex Diaphragm Contraction Vascular Associated Smooth Muscle Cell Migration Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Symbiont-mediated Disruption Of Host Cell PML Body	DNA Replication DNA Replication Initiation DNA Metabolic Process MCM Complex Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process Double-strand Break Repair Via Break-induced Replication Nucleoplasm DNA Replication Origin Binding Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Single-stranded DNA Helicase Activity Origin Recognition Complex Chromosome, Telomeric Region CMG Complex Nucleus Mitotic DNA Replication Initiation DNA Repair Chromosome Single-stranded DNA Binding Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Damage Response Double-strand Break Repair Recombinational Repair Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Chromatin Binding Helicase Activity DNA Strand Elongation DNA Recombination Cellular Response To Stress ATP Hydrolysis Activity DNA Replication Preinitiation Complex Assembly Regulation Of Cell Cycle Phase Transition DNA Binding Regulation Of Cell Cycle DNA Helicase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Sister Chromatid Cohesion Positive Regulation Of DNA Replication Regulation Of Cell Cycle Process Nucleotide Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated DNA Replication
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